⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3538999 | 0.97 | — | — | |
| Hydrochloric Acid SCHEMBL22345173 | 0.95 | — | — | |
| SCHEMBL795214 | 0.89 | — | — | |
| SCHEMBL31133531 | 0.86 | — | — | |
| Ammonia Solution, Strong SCHEMBL11513221 | 0.86 | — | — | |
| SCHEMBL28455077 | 0.86 | — | — | |
| Ethane SCHEMBL2063879 | 0.84 | — | — | |
| Bicarbonate SCHEMBL1161399 | 0.82 | LMNA (0.50) | — | |
| Pyrazine SCHEMBL28055733 | 0.77 | KDM4E (0.48) | — | |
| SCHEMBL32666023 | 0.77 | KDM4E (1.00) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | claimed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | claimed |
| US-20240140983-A1 | SINGLE STRANDED DNA ENZYME INHIBITORS | MASSEY UNIVERSITY (NZ) | 2024-05-02 | — | — | US | disclosed |
| CN-104151221-A | Synthesis method of bis(caproylaminomethyl)-thiourea | YANTAI HENGDIKE ENERGY TECHNOLOGY CO LTD | 2014-11-19 | — | — | CN | disclosed |
| US-8303978-B2 | Controlled release of nitric oxide and drugs from functionalized macromers and oligomers | BEZWADA BIOMEDICAL, LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20120035259-A1 | Controlled Release of Nitric Oxide And Drugs From Functionalized Macromers And Oligomers | BEZWADA BIOCHEMICAL, LLC (US) | 2012-02-09 | — | — | US | disclosed |
| EP-2398761-A2 | CONTROLLED RELEASE OF NITRIC OXIDE AND DRUGS FROM FUNCTIONALIZED MACROMERS AND OLIGOMERS | Bezwada Biomedical, LLC (US) | 2011-12-28 | — | — | EP | disclosed |
| US-8021679-B2 | implantable medical equipment coated with biocompatible polymers based on modified [1,4]oxazepan-7-one, used as in situ time-release agents or drug delivery devices; prevention of restenosis, aneurysms and plaque | MEDTRONIC VASCULAR, INC (US) | 2011-09-20 | — | — | US | disclosed |
| US-8021679-B2 | implantable medical equipment coated with biocompatible polymers based on modified [1,4]oxazepan-7-one, used as in situ time-release agents or drug delivery devices; prevention of restenosis, aneurysms and plaque | MEDTRONIC VASCULAR, INC (US) | 2011-09-20 | — | — | US | disclosed |
| WO-2010096320-A2 | CONTROLLED RELEASE OF NITRIC OXIDE AND DRUGS FROM FUNCTIONALIZED MACROMERS AND OLIGOMERS | BEZWADA BIOMEDICAL, LLC (US) | 2010-08-26 | — | — | WO | disclosed |
| US-20100209469-A1 | Controlled Release of Nitric Oxide And Drugs From Functionalized Macromers And Oligomers | BEZWADA BIOMEDICAL, LLC. (US) | 2010-08-19 | — | — | US | disclosed |
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | disclosed |
| US-20080220048-A1 | implantable medical equipment coated with biocompatible polymers based on modified [1,4]oxazepan-7-one, used as in situ time-release agents or drug delivery devices; prevention of restenosis, aneurysms and plaque | MEDTRONIC VASCULAR, INC. (US) | 2008-09-11 | — | — | US | disclosed |
| EP-1933845-A2 | NITRIC OXIDE-RELEASING BIODEGRADABLE POLYMERS USEFUL AS MEDICAL DEVICES AND COATINGS THEREFORE | Medtronic Vascular, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| EP-1933845-A2 | NITRIC OXIDE-RELEASING BIODEGRADABLE POLYMERS USEFUL AS MEDICAL DEVICES AND COATINGS THEREFORE | Medtronic Vascular, Inc. (US) | 2008-06-25 | — | — | EP | disclosed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |
| WO-2007024501-A3 | NITRIC OXIDE-RELEASING BIODEGRADABLE POLYMERS USEFUL AS MEDICAL DEVICES AND COATINGS THEREFORE | MEDTRONIC VASCULAR INC (US) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007024501-A2 | NITRIC OXIDE-RELEASING BIODEGRADABLE POLYMERS USEFUL AS MEDICAL DEVICES AND COATINGS THEREFORE | MEDTRONIC VASCULAR, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007024501-A2 | NITRIC OXIDE-RELEASING BIODEGRADABLE POLYMERS USEFUL AS MEDICAL DEVICES AND COATINGS THEREFORE | MEDTRONIC VASCULAR, INC. (US) | 2007-03-01 | — | — | WO | disclosed |