Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.50 |
| ▸ | JAK2 | O60674 | 12/20 | 0.48 |
| ▸ | SRC | P12931 | 10/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3529578 | 0.92 | JAK2 (0.47) | KDRJAK2SRCPDGFRB | |
| SCHEMBL3536379 | 0.80 | KDR (0.64) | KDRJAK2SRCPDGFRB | |
| SCHEMBL3532526 | 0.77 | ENPP2 (0.48) | KDRJAK2SRCPDGFRB | |
| SCHEMBL3528695 | 0.75 | KDM4E (0.54) | KDRJAK2SRCPDGFRB | |
| SCHEMBL3528709 | 0.75 | JAK2 (0.57) | KDRJAK2SRCPDGFRB | |
| SCHEMBL3527586 | 0.75 | KDR (0.51) | KDRPDGFRB | |
| SCHEMBL3529695 | 0.74 | KDR (0.53) | KDRPDGFRB | |
| SCHEMBL3530433 | 0.73 | ENPP2 (0.53) | KDRPDGFRB | |
| SCHEMBL5546829 | 0.73 | KDR (0.49) | KDRJAK2SRCPDGFRB | |
| SCHEMBL5545020 | 0.72 | KDR (0.47) | KDRJAK2SRCPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742925-B1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | GRUENENTHAL GMBH (DE) | 2014-04-23 | — | — | EP | claimed |
| EP-1742925-B1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | GRUENENTHAL GMBH (DE) | 2014-04-23 | — | — | EP | disclosed |
| EP-1742925-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005105759-A1 | SUBSTITUTED 5, 6, 7, 8-TETRAHYDRO-PYRIDO[4, 3-D]PYRIMIDINE-2-YL COMPOUNDS AND 5, 6, 7, 8-TETRAHYDRO-QUINAZOLINE-2-YL COMPOUNDS | Grünenthal GmbH (DE) | 2005-11-10 | — | — | WO | disclosed |