Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.60 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.59 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.59 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.59 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.59 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.59 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.58 |
| ▸ | RXRA | P19793 | 1/20 | 0.56 |
| ▸ | RXRB | P28702 | 1/20 | 0.56 |
| ▸ | RXRG | P48443 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5541886 | 0.95 | NOTUM (0.60) | HRH3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5540110 | 0.88 | NOTUM (0.64) | HRH3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL15621589 | 0.82 | NOTUM (0.60) | HRH3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL26616389 | 0.82 | NOTUM (0.60) | HRH3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL14680928 | 0.81 | NOTUM (0.64) | HRH3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL5542686 | 0.81 | NOTUM (0.68) | HRH3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL3045891 | 0.79 | HDAC1 (0.76) | HRH3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL13361951 | 0.79 | HDAC1 (0.61) | HRH3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL4327548 | 0.79 | HDAC1 (0.76) | HRH3HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10247700 | 0.78 | RXRA (0.78) | HRH3HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2570418-A2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles compound | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-03-20 | — | — | EP | disclosed |
| EP-1555267-B1 | 2,3-DIHYDRO-6-NITROIMIDAZO[2,1-b]OXAZOLES | OTSUKA PHARMA CO LTD (JP) | 2013-01-16 | — | — | EP | disclosed |
| US-7262212-B2 | 2,3-dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-08-28 | — | — | US | disclosed |
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-05-04 | — | — | US | disclosed |
| EP-1555267-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO 2,1-b OXAZOLES | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-07-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060094767-A1 | 2,3-Dihydro-6-nitroimidazo[2,1-b]oxazoles | NR2C2, NR4A3, NR4A2 | HRH3 420/4885HDAC3 108/4885HDAC4 707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.