Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 5/20 | 0.61 |
| ▸ | MMP2 | P08253 | 1/20 | 0.61 |
| ▸ | MMP12 | P39900 | 1/20 | 0.61 |
| ▸ | MMP1 | P03956 | 4/20 | 0.56 |
| ▸ | MMP13 | P45452 | 4/20 | 0.56 |
| ▸ | MMP3 | P08254 | 3/20 | 0.56 |
| ▸ | MMP7 | P09237 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SLC18A3 | Q16572 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | BACE1 | P56817 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1656113 | 1.00 | MMP9 (0.61) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1655595 | 0.91 | MMP9 (0.75) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1658419 | 0.89 | MMP9 (0.59) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL5546935 | 0.89 | MMP9 (0.61) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL2925250 | 0.89 | MMP9 (0.61) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL2922365 | 0.88 | MMP9 (0.57) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1655569 | 0.88 | MMP9 (0.60) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL5531373 | 0.88 | MMP9 (0.60) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL2927761 | 0.87 | MMP9 (0.53) | MMP9MMP2MMP12MMP1MMP13 | |
| SCHEMBL1658424 | 0.87 | MMP9 (0.62) | MMP9MMP2MMP12MMP1MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768979-A1 | OCTAHYDROPYRROLO[2, 3, C]PYRIDINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | Applied Research Systems ARS Holding N.V. (AN) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006008303-A1 | OCTAHYDROPYRROLO[2, 3, C]PYRIDINE DERIVATIVES AND PHARMACEUTICAL USE THEREOF | APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. (AN) | 2006-01-26 | — | — | WO | disclosed |