Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.54 |
| ▸ | IP6K1 | Q92551 | 13/20 | 0.51 |
| ▸ | IP6K3 | Q96PC2 | 12/20 | 0.51 |
| ▸ | IP6K2 | Q9UHH9 | 12/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5514440 | 0.85 | ALDH1A1 (0.62) | IP6K1IP6K3IP6K2ALDH1A1KDM4E | |
| SCHEMBL5656312 | 0.82 | IP6K1 (0.55) | IP6K1IP6K3IP6K2ALDH1A1KDM4E | |
| SCHEMBL3559449 | 0.82 | ALDH1A1 (0.58) | IP6K1IP6K3IP6K2ALDH1A1KDM4E | |
| SCHEMBL3549996 | 0.82 | IP6K1 (0.62) | IP6K1IP6K3IP6K2ALDH1A1KDM4E | |
| SCHEMBL5548740 | 0.81 | ALDH1A1 (0.46) | IP6K1IP6K3IP6K2ALDH1A1KDM4E | |
| SCHEMBL5548743 | 0.80 | DOT1L (0.55) | DOT1LALDH1A1KDM4EHTTSMN1; SMN2 | |
| SCHEMBL3554883 | 0.80 | KMT2A (0.61) | IP6K1IP6K3IP6K2ALDH1A1KDM4E | |
| SCHEMBL5656276 | 0.79 | IP6K1 (0.51) | IP6K1IP6K3IP6K2ALDH1A1KDM4E | |
| SCHEMBL5022746 | 0.77 | IP6K1 (0.52) | IP6K1IP6K3IP6K2ALDH1A1KDM4E | |
| SCHEMBL5550324 | 0.76 | KDM4E (0.51) | DOT1LALDH1A1KDM4EHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7196094-B2 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-03-27 | — | — | US | disclosed |
| US-20030207887-A1 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-11-06 | — | — | US | disclosed |
| EP-1322650-A2 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2003-07-02 | — | — | EP | disclosed |
| WO-2002024686-A2 | FARNESYL TRANSFERASE INHIBITING 6-HETEROCYCLYLMETHYL QUINOLINE AND QUINAZOLINE DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-03-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207887-A1 | Farnesyl transferase inhibiting 6-heterocyclylmethyl quinoline and quinazoline derivatives | FNTA, FNTB, RCE1 | DOT1L 1987/4885IP6K1 1477/4885IP6K3 1628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.