Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 13/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.57 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21914319 | 0.92 | ACE (0.53) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL5742165 | 0.88 | ACE (0.64) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL3144462 | 0.88 | ACE (0.64) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL14645812 | 0.86 | ALDH1A1 (0.49) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL14645810 | 0.86 | ALDH1A1 (0.49) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7293220 | 0.85 | ACE (0.57) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL6786409 | 0.85 | ACE (0.57) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL14645896 | 0.84 | ACE (0.59) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL5741647 | 0.83 | MEN1 (0.63) | ACECHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7330019 | 0.83 | MEN1 (0.63) | ACECHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173694-B2 | Therapeutic agent | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2012-05-08 | — | — | US | disclosed |
| US-8173694-B2 | Therapeutic agent | PENTRAXIN THERAPEUTICS LIMITED (GB) | 2012-05-08 | — | — | US | disclosed |