Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 7/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.37 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | GRM8 | O00222 | 1/20 | 0.32 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.32 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27684288 | 0.82 | CYP19A1 (0.46) | CYP19A1SLC6A2SLC6A4SLC6A3CFTR | |
| SCHEMBL5550616 | 0.75 | CYP17A1 (0.47) | CYP19A1KCNH2ALDH1A1 | |
| SCHEMBL1243818 | 0.73 | CYP19A1 (0.49) | CYP19A1SLC6A2SLC6A4SLC6A3CFTR | |
| SCHEMBL29273163 | 0.70 | CYP19A1 (0.57) | CYP19A1 | |
| SCHEMBL28028213 | 0.68 | CFTR (0.46) | CYP19A1SLC6A2SLC6A4SLC6A3CFTR | |
| SCHEMBL1240484 | 0.68 | KCNA5 (0.54) | CYP19A1SMN1; SMN2KCNA5KCNH2 | |
| SCHEMBL27475767 | 0.68 | HRH1 (0.40) | CYP19A1SLC6A2SLC6A4SLC6A3CFTR | |
| SCHEMBL9965186 | 0.68 | CYP19A1 (0.43) | CYP19A1SLC6A2SLC6A4SLC6A3CFTR | |
| SCHEMBL20773275 | 0.67 | CYP19A1 (0.62) | CYP19A1 | |
| SCHEMBL401391 | 0.67 | CYP19A1 (0.53) | CYP19A1SLC6A2SLC6A4SLC6A3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1830858-A2 | 3, 6-BICYCLOLIDES | Enanta Pharmaceuticals, Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006063039-A2 | 3, 6-BICYCLOLIDES | ENANTA PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |