Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 20/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.55 |
| ▸ | CTSS | P25774 | 15/20 | 0.46 |
| ▸ | CTSL | P07711 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4447789 | 0.86 | CTSK (0.62) | CTSKCTSS | |
| SCHEMBL4442745 | 0.77 | CTSK (0.74) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL5022259 | 0.77 | CTSK (0.48) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL13707273 | 0.76 | CTSK (0.69) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL4451832 | 0.73 | CTSK (0.79) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL4444381 | 0.71 | CTSK (1.00) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL13709386 | 0.70 | CTSK (0.52) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL5017270 | 0.67 | CTSK (0.42) | CTSKKCNH2CTSSCTSLCTSB | |
| SCHEMBL5798709 | 0.66 | CTSK (0.71) | CTSKKCNH2CTSSCTSB | |
| SCHEMBL4442123 | 0.65 | TLR8 (0.34) | CTSKKCNH2CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758870-A1 | 4-PHENYL-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | N.V. Organon (NL) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005121106-A1 | 4-PHENYL-PYRIMIDINE-2-CARBONITRILE DERIVATIVES | N.V. ORGANON (NL) | 2005-12-22 | — | — | WO | disclosed |