Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5025239 | 0.90 | NPC1 (0.42) | NPC1RAB9AKDM4EHSD17B10TP53 | |
| SCHEMBL5025403 | 0.88 | NPC1 (0.34) | NPC1RAB9ALMNAPDE4D | |
| SCHEMBL5016524 | 0.83 | TDP1 (0.43) | NPC1RAB9ATDP1LRRK2KDM4E | |
| SCHEMBL5018082 | 0.82 | NPC1 (0.44) | NPC1RAB9ATDP1MAPTLRRK2 | |
| SCHEMBL4035701 | 0.80 | LMNA (0.37) | NPC1RAB9AMAPTLMNAKMT2A | |
| SCHEMBL6533419 | 0.72 | BTK (0.38) | NPC1RAB9AMAPTKDM4EKMT2A | |
| SCHEMBL5023305 | 0.71 | GSTP1 (0.37) | NPC1RAB9AMAPTKDM4ETP53 | |
| SCHEMBL5018010 | 0.71 | MAP2K1 (0.37) | NPC1RAB9ATDP1MAPTKDM4E | |
| SCHEMBL6532850 | 0.71 | MEN1 (0.39) | NPC1RAB9AMAPTKDM4ETP53 | |
| SCHEMBL5025324 | 0.71 | GAA (0.39) | NPC1RAB9ATDP1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1554262-B1 | NOVEL TRICYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS: PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLENMARK PHARMACEUTICALS LTD (IN) | 2007-12-05 | — | — | EP | claimed |