Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.51 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.51 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.51 |
| ▸ | DNM1 | Q05193 | 10/20 | 0.67 |
| ▸ | HTT | P42858 | 4/20 | 0.65 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | RAD52 | P43351 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | MLNR | O43193 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.51 |
| ▸ | PGR | P06401 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5027866 | 1.00 | DNM1 (0.67) | DNM1HTTHSP90AA1RAD52LMNA | |
| Bromide SCHEMBL399887 | 1.00 | DNM1 (0.67) | DNM1HTTHSP90AA1RAD52LMNA | |
| Bromide SCHEMBL10570439 | 1.00 | DNM1 (0.67) | DNM1HTTHSP90AA1RAD52LMNA | |
| SCHEMBL4807333 | 0.98 | HTT (0.68) | DNM1HTTHSP90AA1RAD52LMNA | |
| SCHEMBL13714974 | 0.98 | HTT (0.68) | DNM1HTTHSP90AA1RAD52LMNA | |
| SCHEMBL4806690 | 0.98 | HTT (0.68) | DNM1HTTHSP90AA1RAD52LMNA | |
| SCHEMBL5944514 | 0.98 | HTT (0.68) | DNM1HTTHSP90AA1RAD52LMNA | |
| Hydrochloric Acid SCHEMBL8652995 | 0.96 | HTT (0.65) | DNM1HTTHSP90AA1RAD52LMNA | |
| Hydrochloric Acid SCHEMBL10492664 | 0.96 | HTT (0.65) | DNM1HTTHSP90AA1RAD52LMNA | |
| SCHEMBL5944756 | 0.96 | HTT (0.64) | DNM1HTTHSP90AA1RAD52LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007030117-A2 | MULTIFUNCTIONAL SELF-DECONTAMINATING SURFACE COATING | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF THE NAVY (US) | 2007-03-15 | — | — | WO | disclosed |
| US-4883917-A | Quaternary ammonium compounds | ETHYL CORPORATION (US) | 1989-11-28 | — | — | US | disclosed |
| US-4874788-A | BACTERICIDES | ETHYL CORPORATION (US) | 1989-10-17 | — | — | US | disclosed |
| US-4874789-A | BACTERICIDES | ETHYL CORPORATION (US) | 1989-10-17 | — | — | US | disclosed |
| US-4874785-A | BACTERICIDES | ETHYL CORPORATION (US) | 1989-10-17 | — | — | US | disclosed |
| US-4874784-A | BACTERICIDES | ETHYL CORPORATION (US) | 1989-10-17 | — | — | US | disclosed |
| US-4824867-A | BACTERICIDES | ALBERMARLE CORPORATION | 1989-04-25 | — | — | US | disclosed |