Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 7/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 3/20 | 0.48 |
| ▸ | LCK | P06239 | 8/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.46 |
| ▸ | BTK | Q06187 | 5/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17603567 | 0.89 | LCK (0.49) | BRAFCSF1RLCKKITABL1 | |
| SCHEMBL5648242 | 0.80 | RAF1 (0.53) | BRAF | |
| SCHEMBL1830846 | 0.79 | BRAF (0.47) | BRAFBTK | |
| SCHEMBL13269850 | 0.79 | LCK (0.46) | BRAFLCKABL1SRCMAPK14 | |
| SCHEMBL19666704 | 0.78 | ABL1 (0.51) | LCKABL1 | |
| SCHEMBL1824860 | 0.73 | BRAF (0.58) | BRAFCSF1RLCKSRC | |
| SCHEMBL4964301 | 0.72 | LCK (0.57) | BRAFLCKSRC | |
| SCHEMBL3241890 | 0.71 | BRAF (0.67) | BRAFCSF1RKITPIKFYVE | |
| SCHEMBL16180799 | 0.71 | LCK (0.58) | BRAFLCKSRCMAPK14BTK | |
| SCHEMBL4962465 | 0.70 | LCK (0.61) | BRAFLCKSRCMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758892-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123719-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-12-29 | — | — | WO | disclosed |