Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | APEX1 | P27695 | 1/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | ARAF | P10398 | 3/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547677 | 0.79 | BRAF (0.51) | BRAFBTK | |
| SCHEMBL17603567 | 0.78 | LCK (0.49) | BRAFKDRBTK | |
| SCHEMBL19666704 | 0.77 | ABL1 (0.51) | MAPT | |
| SCHEMBL3233227 | 0.74 | BRAF (0.53) | BRAFKDRPOLBMAPTAPEX1 | |
| SCHEMBL5548581 | 0.73 | NR2C2 (0.57) | BRAFRAF1 | |
| SCHEMBL16180562 | 0.70 | BTK (0.43) | GRM4BTK | |
| SCHEMBL13878794 | 0.70 | LCK (0.55) | BRAFPOLBMAPTAPEX1GRM4 | |
| SCHEMBL21116416 | 0.69 | BRAF (0.61) | BRAFRAF1ARAF | |
| SCHEMBL13269850 | 0.69 | LCK (0.46) | BRAFKDRRAF1 | |
| SCHEMBL28679461 | 0.67 | BRAF (0.49) | BRAFKDRGRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4688876-B2 | — | — | 2011-05-25 | — | — | JP | claimed |
| EP-1758892-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-03-07 | — | — | EP | claimed |
| WO-2005123719-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-12-29 | — | — | WO | claimed |