Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 5/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 9/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2686406 | 0.90 | ABCB1 (0.61) | ABCB1HDAC2HDAC3HDAC1 | |
| SCHEMBL2684552 | 0.89 | HDAC1 (0.56) | ABCB1HDAC2HDAC3HDAC1POLB | |
| SCHEMBL2684600 | 0.89 | HDAC2 (0.61) | ABCB1HDAC2HDAC3HDAC1 | |
| SCHEMBL2685468 | 0.86 | HDAC1 (0.51) | HDAC2HDAC3HDAC1 | |
| SCHEMBL2687804 | 0.85 | HDAC1 (0.50) | HDAC2HDAC3HDAC1 | |
| SCHEMBL2686862 | 0.81 | HDAC1 (0.58) | ABCB1HDAC2HDAC3HDAC1POLB | |
| SCHEMBL14775932 | 0.80 | HDAC2 (0.46) | ABCB1HDAC2HDAC3HDAC1 | |
| SCHEMBL2685916 | 0.80 | HDAC2 (0.61) | HDAC2HDAC3HDAC1 | |
| SCHEMBL2685834 | 0.79 | ABCB1 (0.49) | ABCB1HDAC2HDAC3HDAC1 | |
| SCHEMBL2685588 | 0.79 | HDAC2 (0.61) | HDAC2HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168658-B2 | Inhibitors of histone deacetylase | MERCK SHARP & DOHME CORP. (US) | 2012-05-01 | — | — | US | disclosed |
| US-8168658-B2 | Inhibitors of histone deacetylase | MERCK SHARP & DOHME CORP. (US) | 2012-05-01 | — | — | US | disclosed |
| US-20090069250-A1 | Inhibitors of Histone Deacetylase | MERCK SHARP & DOHME LLC | 2009-03-12 | — | — | US | disclosed |
| US-20090069250-A1 | Inhibitors of Histone Deacetylase | MERCK SHARP & DOHME LLC | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069250-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC6 | ABCB1 3319/4885HDAC2 4/4885HDAC3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.