Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 12/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.36 |
| ▸ | NCOR2 | Q9Y618 | 2/20 | 0.36 |
| ▸ | GCGR | P47871 | 5/20 | 0.36 |
| ▸ | ADCY6 | O43306 | 3/20 | 0.36 |
| ▸ | ADCY3 | O60266 | 3/20 | 0.36 |
| ▸ | ADCY9 | O60503 | 3/20 | 0.36 |
| ▸ | ADCY5 | O95622 | 3/20 | 0.36 |
| ▸ | ADCY8 | P40145 | 3/20 | 0.36 |
| ▸ | ADCY7 | P51828 | 3/20 | 0.36 |
| ▸ | ADCY2 | Q08462 | 3/20 | 0.36 |
| ▸ | ADCY1 | Q08828 | 3/20 | 0.36 |
| ▸ | ADCY4 | Q8NFM4 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | PLG | P00747 | 1/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5544366 | 0.93 | HDAC1 (0.45) | HDAC1HDAC2HDAC3NCOR2GCGR | |
| SCHEMBL2686960 | 0.91 | HDAC1 (0.41) | HDAC1HDAC2HDAC3F2F10 | |
| SCHEMBL2685976 | 0.90 | HDAC1 (0.44) | HDAC1HDAC2HDAC3NCOR2GCGR | |
| SCHEMBL2685761 | 0.89 | HDAC1 (0.40) | HDAC1HDAC2HDAC3F2F10 | |
| SCHEMBL5548615 | 0.87 | HDAC1 (0.42) | HDAC1HDAC2HDAC3NCOR2GCGR | |
| SCHEMBL2685888 | 0.85 | HDAC1 (0.58) | HDAC1HDAC2HDAC3NCOR2 | |
| SCHEMBL2686835 | 0.82 | HDAC1 (0.50) | HDAC1HDAC2HDAC3NCOR2GCGR | |
| SCHEMBL13913374 | 0.79 | HDAC1 (0.42) | HDAC1HDAC2HDAC3P2RY14 | |
| SCHEMBL2685023 | 0.79 | HDAC1 (0.61) | HDAC1HDAC2HDAC3HDAC4HDAC7 | |
| SCHEMBL4781161 | 0.78 | HDAC1 (0.51) | HDAC1HDAC2HDAC3NCOR2GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8168658-B2 | Inhibitors of histone deacetylase | MERCK SHARP & DOHME CORP. (US) | 2012-05-01 | — | — | US | disclosed |
| US-20090069250-A1 | Inhibitors of Histone Deacetylase | MERCK SHARP & DOHME LLC | 2009-03-12 | — | — | US | disclosed |
| WO-2007100657-A2 | INHIBITORS OF HISTONE DEACETYLASE | MERCK & CO., INC. (US) | 2007-09-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069250-A1 | Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC6 | HDAC1 1/4885HDAC2 4/4885HDAC3 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.