SCHEMBL5548615

SCHEMBL5548615

CN(C)CC(C(=O)Nc1ccccc1)c1ccc(C(=O)Nc2cc(-c3ccsc3)ccc2NC(=O)OC(C)(C)C)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 16/20 0.42
HDAC2 Q92769 8/20 0.38
HDAC3 O15379 7/20 0.38
NCOR2 Q9Y618 2/20 0.38
ADCY6 O43306 1/20 0.36
ADCY3 O60266 1/20 0.36
ADCY9 O60503 1/20 0.36
ADCY5 O95622 1/20 0.36
ADCY8 P40145 1/20 0.36
GCGR P47871 1/20 0.36
ADCY7 P51828 1/20 0.36
ADCY2 Q08462 1/20 0.36
ADCY1 Q08828 1/20 0.36
ADCY4 Q8NFM4 1/20 0.36
HDAC4 P56524 4/20 0.36
NAMPT P43490 1/20 0.35
HDAC7 Q8WUI4 3/20 0.35
HDAC10 Q969S8 3/20 0.35
HDAC11 Q96DB2 3/20 0.35
HDAC8 Q9BY41 3/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2686087 0.90 HDAC1 (0.46) HDAC1HDAC2HDAC3NCOR2HDAC4
SCHEMBL5544366 0.89 HDAC1 (0.45) HDAC1HDAC2HDAC3NCOR2ADCY6
SCHEMBL5548010 0.87 HDAC1 (0.41) HDAC1HDAC2HDAC3NCOR2ADCY6
SCHEMBL13913374 0.87 HDAC1 (0.42) HDAC1HDAC2HDAC3P2RY14ABCB1
SCHEMBL2685764 0.85 HDAC1 (0.60) HDAC1HDAC2HDAC3NCOR2
SCHEMBL4779009 0.83 HDAC1 (0.45) HDAC1HDAC2HDAC3NCOR2HDAC4
SCHEMBL651518 0.79 HDAC1 (0.52) HDAC1HDAC2HDAC3HDAC4HDAC7
SCHEMBL2686960 0.79 HDAC1 (0.41) HDAC1HDAC2HDAC3HDAC6P2RY14
SCHEMBL10121375 0.78 HDAC1 (0.49) HDAC1HDAC2HDAC3HDAC4NAMPT
SCHEMBL2686835 0.78 HDAC1 (0.50) HDAC1HDAC2HDAC3NCOR2ADCY6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8168658-B2 Inhibitors of histone deacetylase MERCK SHARP & DOHME CORP. (US) 2012-05-01 US disclosed
WO-2007100657-A2 INHIBITORS OF HISTONE DEACETYLASE MERCK & CO., INC. (US) 2007-09-07 WO disclosed