Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR2C2 | P49116 | 8/20 | 0.57 |
| ▸ | HCK | P08631 | 7/20 | 0.57 |
| ▸ | MAP3K7 | O43318 | 7/20 | 0.57 |
| ▸ | MAP4K2 | Q12851 | 7/20 | 0.57 |
| ▸ | MAPK14 | Q16539 | 6/20 | 0.57 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.55 |
| ▸ | FES | P07332 | 4/20 | 0.54 |
| ▸ | FER | P16591 | 4/20 | 0.54 |
| ▸ | GCK | P35557 | 2/20 | 0.54 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | RAF1 | P04049 | 1/20 | 0.52 |
| ▸ | LYN | P07948 | 1/20 | 0.52 |
| ▸ | SRC | P12931 | 1/20 | 0.52 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.52 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
| ▸ | CSK | P41240 | 1/20 | 0.52 |
| ▸ | ABL2 | P42684 | 1/20 | 0.52 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3828768 | 0.77 | HCK (0.58) | NR2C2HCKMAP3K7MAP4K2MAPK14 | |
| SCHEMBL1826484 | 0.77 | NR2C2 (0.58) | NR2C2HCKMAP3K7MAP4K2MAPK14 | |
| SCHEMBL3234828 | 0.76 | NR2C2 (0.59) | NR2C2HCKMAP3K7MAP4K2MAPK14 | |
| SCHEMBL3830805 | 0.76 | NR2C2 (0.58) | NR2C2HCKMAP3K7MAP4K2MAPK14 | |
| SCHEMBL16809203 | 0.74 | NR2C2 (0.85) | NR2C2HCKMAP3K7MAP4K2MAPK14 | |
| SCHEMBL30967729 | 0.74 | NR2C2 (0.85) | NR2C2HCKMAP3K7MAP4K2MAPK14 | |
| SCHEMBL1830846 | 0.73 | BRAF (0.47) | RAF1BRAF | |
| SCHEMBL30967732 | 0.73 | NR2C2 (1.00) | NR2C2HCKMAP3K7MAP4K2MAPK14 | |
| SCHEMBL16809250 | 0.73 | NR2C2 (1.00) | NR2C2HCKMAP3K7MAP4K2MAPK14 | |
| SCHEMBL16809252 | 0.73 | NR2C2 (1.00) | NR2C2HCKMAP3K7MAP4K2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758892-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2007-03-07 | — | — | EP | disclosed |
| WO-2005123719-A1 | COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2005-12-29 | — | — | WO | disclosed |