SCHEMBL554860

SCHEMBL554860

O=P(O)(O)OP(=O)(O)Oc1c(Cl)c(Cl)c(Cl)c(Cl)c1Cl

nearest known ligand 0.41

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
FDPS P14324 1/20 0.39
BLM P54132 1/20 0.39
TDP1 Q9NUW8 1/20 0.39
INPPL1 O15357 5/20 0.32
INPP5A Q14642 4/20 0.32
AKT1 P31749 1/20 0.32
BTN3A1 O00481 3/20 0.31
INPP5B P32019 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14956572 0.98 FDPS (0.38) FDPSBLMTDP1INPPL1INPP5A
SCHEMBL7046327 0.90 MEN1 (0.37) FDPSBLMTDP1
SCHEMBL574460 0.80 INPPL1 (0.48) FDPSBLMTDP1INPPL1INPP5A
SCHEMBL10751352 0.78 INPPL1 (0.46) FDPSBLMTDP1INPPL1INPP5A
SCHEMBL28491120 0.73 FDPS (0.39) FDPSBLMTDP1INPPL1INPP5A
SCHEMBL4181363 0.71 FDPS (0.38) FDPSBLMTDP1INPPL1INPP5A
Pyrophosphoric Acid SCHEMBL29037352 0.68 FDPS (0.71) FDPSBLMTDP1INPPL1INPP5A
Triphosphate SCHEMBL18714 0.68 FDPS (0.69) FDPSBLMTDP1INPPL1INPP5A
Triphosphate SCHEMBL15555988 0.68 FDPS (0.69) FDPSBLMTDP1INPPL1INPP5A
SCHEMBL11334192 0.67 CA1 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11746338-B2 Recombinant polymerases for improved single molecule sequencing PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2023-09-05 US disclosed
US-10975362-B2 Recombinant polymerases for improved single molecule sequencing PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2021-04-13 US disclosed
US-20190249153-A1 RECOMBINANT POLYMERASES FOR IMPROVED SINGLE MOLECULE SEQUENCING PACIFIC BIOSCIENCES CALIFORNIA INC (US) 2019-08-15 US disclosed
US-10167455-B2 Recombinant polymerases for improved single molecule sequencing PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2019-01-01 US disclosed
US-20170327801-A1 RECOMBINANT POLYMERASES FOR IMPROVED SINGLE MOLECULE SEQUENCING PACIFIC BIOSCIENCES CALIFORNIA INC (US) 2017-11-16 US disclosed
US-9719073-B2 Recombinant polymerases for improved single molecule sequencing PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2017-08-01 US disclosed
US-20150240221-A1 Recombinant Polymerases for Improved Single Molecule Sequencing PACIFIC BIOSCIENCES CALIFORNIA (US) 2015-08-27 US disclosed
US-8999676-B2 Recombinant polymerases for improved single molecule sequencing PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2015-04-07 US disclosed
US-8420366-B2 Generation of modified polymerases for improved accuracy in single molecule sequencing PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2013-04-16 US disclosed
US-20120034602-A1 Recombinant Polymerases For Improved Single Molecule Sequencing PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2012-02-09 US disclosed
US-20110189659-A1 Generation of modified polymerases for improved accuracy in single molecule sequencing PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2011-08-04 US disclosed
WO-2011040971-A9 GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2011-08-04 WO disclosed
WO-2011040971-A2 GENERATION OF MODIFIED POLYMERASES FOR IMPROVED ACCURACY IN SINGLE MOLECULE SEQUENCING PACIFIC BIOSCIENCES OF CALIFORNIA, INC. (US) 2011-04-07 WO disclosed