Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 19/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27742035 | 0.83 | TRPV1 (0.47) | TRPV1CYP3A4CYP2D6CFTR | |
| SCHEMBL3321990 | 0.78 | TRPV1 (0.49) | TRPV1CYP3A4CYP2D6CFTR | |
| SCHEMBL1985673 | 0.77 | TRPV1 (0.65) | TRPV1CYP3A4CYP2D6 | |
| SCHEMBL27762597 | 0.77 | TRPV1 (0.46) | TRPV1CYP3A4CYP2D6CFTR | |
| SCHEMBL5551974 | 0.70 | TRPV1 (0.46) | TRPV1CYP3A4CYP2D6 | |
| SCHEMBL3323722 | 0.69 | TRPV1 (0.54) | TRPV1CYP3A4CYP2D6 | |
| SCHEMBL3322856 | 0.68 | TRPV1 (0.51) | TRPV1CYP3A4CYP2D6 | |
| SCHEMBL3322270 | 0.67 | TRPV1 (0.54) | TRPV1CYP3A4CFTR | |
| SCHEMBL4140742 | 0.67 | TRPV1 (0.49) | TRPV1CYP3A4CFTR | |
| SCHEMBL4137513 | 0.67 | TRPV1 (0.49) | TRPV1CYP3A4CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102161653-A | Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor and uses thereof | ABBOTT LAB | 2011-08-24 | — | — | CN | claimed |
| CN-101443327-A | Chromanylurea compounds that inhibit vanilloid receptor subtype 1(VR1) receptor and uses thereof | ABBOTT LAB (US) | 2009-05-27 | — | — | CN | claimed |
| EP-1844038-A2 | CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF | ABBOTT LABORATORIES (US) | 2007-10-17 | — | — | EP | claimed |
| WO-2006065484-A2 | CHROMANYLUREA COMPOUNDS THAT INHIBIT VANILLOID RECEPTOR SUBTYPE 1 (VR1) RECEPTOR AND USES THEREOF | ABBOTT LABORATORIES (US) | 2006-06-22 | — | — | WO | claimed |
| CN-102161653-A | Chromanylurea compounds that inhibit vanilloid receptor subtype 1 (vr1) receptor and uses thereof | ABBOTT LAB | 2011-08-24 | — | — | CN | disclosed |