Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.69 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ABL2 | P42684 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.47 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.46 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4049135 | 0.88 | MAPK14 (0.69) | MAPK14ABL1ABL2MAPK8MAPK11 | |
| SCHEMBL2083369 | 0.85 | MAPK14 (0.71) | MAPK14ABL1ABL2MAPK8MAPK11 | |
| SCHEMBL2079106 | 0.85 | MAPK14 (0.68) | MAPK14ABL1ABL2MAPK8MAPK11 | |
| SCHEMBL5549496 | 0.83 | MAPK14 (0.69) | MAPK14ABL1ABL2MAPK8MAPK11 | |
| SCHEMBL4052308 | 0.82 | MAPK14 (0.82) | MAPK14ABL1ABL2MAPK8MAPK11 | |
| SCHEMBL2082516 | 0.82 | MAPK14 (1.00) | MAPK14ABL1ABL2MAPK8MAPK11 | |
| SCHEMBL2082534 | 0.81 | MAPK14 (0.86) | MAPK14ABL1ABL2MAPK8MAPK11 | |
| SCHEMBL2084044 | 0.79 | MAPK14 (0.86) | MAPK14ABL1ABL2MAPK8MAPK11 | |
| SCHEMBL4302272 | 0.79 | MAPK14 (0.74) | MAPK14ABL1ABL2MAPK8MAPK11 | |
| SCHEMBL2084896 | 0.79 | MAPK14 (0.64) | MAPK14ABL1ABL2MAPK8MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1835934-A2 | ENZYME MODULATORS AND TREATMENTS | Deciphera Pharmaceuticals, LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006071940-A2 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2006-07-06 | — | — | WO | disclosed |