Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 18/20 | 0.77 |
| ▸ | CRBN | Q96SW2 | 18/20 | 0.77 |
| ▸ | IKZF3 | Q9UKT9 | 2/20 | 0.55 |
| ▸ | TNF | P01375 | 1/20 | 0.55 |
| ▸ | IL1B | P01584 | 1/20 | 0.55 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.55 |
| ▸ | IKZF1 | Q13422 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2381286 | 0.91 | DDB1 (0.77) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL476960 | 0.89 | DDB1 (0.81) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL30041341 | 0.89 | DDB1 (0.81) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL30009748 | 0.88 | DDB1 (0.80) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL476904 | 0.88 | DDB1 (0.80) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL1424775 | 0.88 | DDB1 (0.79) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL20118479 | 0.88 | DDB1 (0.79) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL20118388 | 0.88 | DDB1 (0.79) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL2382971 | 0.87 | DDB1 (0.78) | DDB1CRBNIKZF3TNFIL1B | |
| SCHEMBL12250735 | 0.87 | DDB1 (1.00) | DDB1CRBNIKZF3TNFIL1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1363900-B1 | ISOINDOLE-IMIDE COMPOUNDS, COMPOSITIONS AND USES THEREOF | CELGENE CORP (US) | 2007-01-24 | — | — | EP | claimed |