Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 5/20 | 0.49 |
| ▸ | GSK3B | P49841 | 5/20 | 0.49 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3527708 | 0.92 | GSK3A (0.57) | GSK3AGSK3BKMT2ARAB9ALMNA | |
| SCHEMBL3529920 | 0.91 | GSK3A (0.61) | GSK3AGSK3BKMT2ARAB9ALMNA | |
| SCHEMBL3525341 | 0.91 | GSK3B (0.48) | GSK3AGSK3BAURKACYP2D6RAB9A | |
| SCHEMBL5549831 | 0.90 | GSK3A (0.50) | GSK3AGSK3BRAB9ALMNAHTT | |
| SCHEMBL3521643 | 0.89 | GSK3A (0.43) | GSK3AGSK3BKMT2AAURKACYP2D6 | |
| SCHEMBL3530232 | 0.89 | GSK3A (0.46) | GSK3AGSK3BGPR84AURKACYP3A4 | |
| SCHEMBL5549009 | 0.87 | GSK3A (0.43) | GSK3AGSK3BKMT2AADORA1CYP3A4 | |
| SCHEMBL5550212 | 0.87 | GSK3A (0.44) | GSK3AGSK3BKMT2ALMNAHTT | |
| SCHEMBL5548604 | 0.86 | GSK3A (0.48) | GSK3AGSK3BAURKACYP3A4CYP2D6 | |
| SCHEMBL5548595 | 0.85 | GSK3B (0.48) | GSK3AGSK3BLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678180-B1 | SUBSTITUTED 2H-[1,2,4]TRIAZOLO 4,3-A PYRAZINES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2007-08-08 | — | — | EP | disclosed |