Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.50 |
| ▸ | MEN1 | O00255 | 5/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 9/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.42 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.42 |
| ▸ | KCNJ6 | P48051 | 1/20 | 0.42 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.42 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.42 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2082943 | 0.85 | MAPK14 (0.62) | RAB9AKMT2AMEN1MAPTMAPK14 | |
| SCHEMBL2082310 | 0.77 | MAPK14 (0.61) | RAB9AKMT2AMEN1MAPTMAPK14 | |
| SCHEMBL2083662 | 0.77 | MAPK14 (0.72) | RAB9AKMT2AMEN1MAPTMAPK14 | |
| SCHEMBL4302686 | 0.76 | MAPK14 (0.59) | RAB9AKMT2AMEN1MAPTMAPK14 | |
| SCHEMBL2083034 | 0.75 | MAPK14 (0.60) | RAB9AKMT2AMEN1MAPTMAPK14 | |
| SCHEMBL4299075 | 0.75 | MAPK14 (0.72) | RAB9AKMT2AMEN1MAPTMAPK14 | |
| SCHEMBL14190095 | 0.74 | MAPK14 (0.57) | RAB9AKMT2AMEN1MAPTMAPK14 | |
| SCHEMBL2081660 | 0.74 | MAPK14 (0.62) | RAB9AMAPK14 | |
| SCHEMBL2082979 | 0.74 | MAPK14 (0.72) | RAB9AKMT2AMEN1MAPTMAPK14 | |
| SCHEMBL4055651 | 0.73 | KCNJ6 (0.56) | KMT2AMEN1MAPK14KCNJ6KCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1835934-A2 | ENZYME MODULATORS AND TREATMENTS | Deciphera Pharmaceuticals, LLC (US) | 2007-09-26 | — | — | EP | disclosed |
| WO-2006071940-A2 | ENZYME MODULATORS AND TREATMENTS | DECIPHERA PHARMACEUTICALS, LLC (US) | 2006-07-06 | — | — | WO | disclosed |