Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.80 |
| ▸ | DPP8 | Q6V1X1 | 9/20 | 0.66 |
| ▸ | DPP9 | Q86TI2 | 9/20 | 0.66 |
| ▸ | FAP | Q12884 | 8/20 | 0.66 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3157260 | 0.99 | DPP4 (0.79) | DPP4DPP8DPP9FAPDPP7 | |
| Denagliptin SCHEMBL2552817 | 0.89 | DPP4 (1.00) | DPP4DPP8DPP9FAPDPP7 | |
| Denagliptin SCHEMBL18815071 | 0.89 | DPP4 (1.00) | DPP4DPP8DPP9FAPDPP7 | |
| Denagliptin SCHEMBL682185 | 0.89 | DPP4 (1.00) | DPP4DPP8DPP9FAPDPP7 | |
| Denagliptin SCHEMBL987759 | 0.89 | DPP4 (1.00) | DPP4DPP8DPP9FAPDPP7 | |
| Denagliptin SCHEMBL1035624 | 0.89 | DPP4 (1.00) | DPP4DPP8DPP9FAPDPP7 | |
| Denagliptin SCHEMBL3151455 | 0.88 | DPP4 (0.98) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL13986697 | 0.84 | DPP4 (0.89) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL8353579 | 0.82 | DPP4 (0.55) | DPP4DPP8DPP9FAPDPP7 | |
| SCHEMBL14421527 | 0.80 | DPP4 (0.68) | DPP4DPP8DPP9FAPDPP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406873-B1 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-09-26 | — | — | EP | claimed |
| EP-1406873-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-14 | — | — | EP | claimed |
| WO-2003002531-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-09 | — | — | WO | claimed |
| EP-1406873-B1 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORP (US) | 2007-09-26 | — | — | EP | disclosed |
| EP-1406873-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003002531-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-09 | — | — | WO | disclosed |
| WO-2003002531-A2 | FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-09 | — | — | WO | disclosed |