Denagliptin

Denagliptin

SCHEMBL682185

N#C[C@@H]1C[C@H](F)CN1C(=O)[C@@H](N)C(c1ccc(F)cc1)c1ccc(F)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
DPP4 P27487 20/20 1.00
FAP Q12884 10/20 0.67
DPP8 Q6V1X1 9/20 0.67
DPP9 Q86TI2 9/20 0.67
DPP7 Q9UHL4 9/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Denagliptin SCHEMBL2552817 1.00 DPP4 (1.00) DPP4FAPDPP8DPP9DPP7
Denagliptin SCHEMBL987759 1.00 DPP4 (1.00) DPP4FAPDPP8DPP9DPP7
Denagliptin SCHEMBL18815071 1.00 DPP4 (1.00) DPP4FAPDPP8DPP9DPP7
Denagliptin SCHEMBL1035624 1.00 DPP4 (1.00) DPP4FAPDPP8DPP9DPP7
Denagliptin SCHEMBL3151455 0.99 DPP4 (0.98) DPP4FAPDPP8DPP9DPP7
SCHEMBL13986697 0.94 DPP4 (0.89) DPP4FAPDPP8DPP9DPP7
SCHEMBL5549926 0.89 DPP4 (0.80) DPP4FAPDPP8DPP9DPP7
Hydrochloric Acid SCHEMBL3157260 0.88 DPP4 (0.79) DPP4FAPDPP8DPP9DPP7
Denagliptin SCHEMBL4801510 0.87 DPP4 (0.76) DPP4FAPDPP8DPP9DPP7
SCHEMBL12350113 0.87 DPP4 (0.77) DPP4FAPDPP8DPP9DPP7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1990 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4686474-A1 DPP-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF AUTOIMMUNE LIVER DISEASES Delta 4 GmbH (AT) 2026-02-04 EP claimed
EP-3787631-B1 MODULATORS OF ORPHAN NUCLEAR RECEPTORS FOR NASH AND OTHER METABOLIC DISORDERS UNIV EMORY (US) 2025-09-10 EP claimed
EP-4554574-A2 SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES The Scripps Research Institute (US) 2025-05-21 EP claimed
WO-2025057088-A1 RNA COMPOSITIONS FOR DELIVERY OF INCRETIN AGENTS BioNTech SE (DE) 2025-03-20 WO claimed
EP-3804715-B1 PHARMACEUTICAL COMBINATION, COMPOSITION AND COMPOUND PREPARATION COMPRISING GLUCOKINASE ACTIVATOR AND DPP-IV INHIBITOR, AND PREPARATION METHOD AND USE THEREOF HUA MEDICINE SHANGHAI LTD (CN) 2024-12-25 EP claimed
US-20240299357-A1 PHARMACEUTICAL COMBINATION, COMPOSITION AND COMPOUND PREPARATION COMPRISING GLUCOKINASE ACTIVATOR AND DPP-IV INHIBITOR, AND PREPARATION METHOD AND USE THEREOF HUA MEDICINE (SHANGHAI) LIMITED (CN) 2024-09-12 US claimed
US-20240115577-A1 SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES THE SCRIPPS RESEARCH INSTITUTE 2024-04-11 US claimed
US-20240100048-A1 DIPEPTIDYLPEPTIDASE 4 INHIBITION ENHANCES LYMPHOCYTE TRAFFICKING, IMPROVING BOTH NATURALLY OCCURRING TUMOR IMMUNITY AND IMMUNOTHERAPY INSTITUT PASTEUR (FR) 2024-03-28 US claimed
US-11883398-B2 Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy INSTITUT PASTEUR (FR) 2024-01-30 US claimed
WO-2024015889-A2 SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES THE SCRIPPS RESEARCH INSTITUTE (US) 2024-01-18 WO claimed
EP-3323818-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO Arena Pharmaceuticals, Inc. (US) 2018-05-23 EP claimed
US-20140066369-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-03-06 US claimed
US-20140051629-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2014-02-20 US claimed
US-20140051714-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-02-20 US claimed
US-20140038889-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-02-06 US claimed
US-20140018371-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto ARENA PHARMACEUTICALS, INC. (US) 2014-01-16 US claimed
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO ARENA PHARMACEUTICALS, INC. (US) 2013-01-24 US claimed
WO-2011005929-A1 PIPERIDINE DERIVATIVE AND ITS USE FOR THE TREATMENT OF DIABETS AND OBESITY ARENA PHARMACEUTICALS, INC. (US) 2011-01-13 WO claimed
EP-1654226-B1 (2S,4S)-4-FLUORO-1- 4-FLUORO-BETA-(4-FLUOROPHENYL)-L-PHENYLALANYL -2-PYRROLIDINECARBONITRILE P-TOLUENESULFONIC ACID SALT AND ANHYDROUS CRYSTALLINE FORMS THEREOF SMITHKLINE BEECHAM CORP (US) 2008-10-22 EP claimed
EP-1406873-B1 FLUOROPYRROLIDINES AS DIPEPTIDYL PEPTIDASE INHIBITORS SMITHKLINE BEECHAM CORP (US) 2007-09-26 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240299357-A1 PHARMACEUTICAL COMBINATION, COMPOSITION AND COMPOUND PREPARATION COMPRISING GLUCOKINASE ACTIVATOR AND DPP-IV INHIBITOR, AND PREPARATION METHOD AND USE THEREOF DPP4, DPP7, DPP8 DPP4 1/4885FAP 91/4885DPP8 3/4885
US-20140038889-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GLP1R, DPP4 DPP4 3/4885FAP 365/4885DPP8 15/4885
US-20130023494-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO GPR119, SLC5A2, SLC5A1 DPP4 10/4885FAP 882/4885DPP8 41/4885
US-20240115577-A1 SMALL MOLECULE REGULATORS OF ALVEOLAR TYPE 2 CELL PROLIFERATION FOR THE TREATMENT OF PULMONARY DISEASES DPP4, DPP7, ING2 DPP4 1/4885FAP 850/4885DPP8 8/4885
US-20140051629-A1 MODULATORS OF THE GPR119 RECEPTOR AND THE TREATMENT OF DISORDERS RELATED THERETO GPR119, GLP1R, DPP4 DPP4 3/4885FAP 366/4885DPP8 10/4885
US-20140051714-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GLP1R, DPP4 DPP4 3/4885FAP 416/4885DPP8 11/4885
US-20140066369-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GLP1R, SLC5A2 DPP4 6/4885FAP 939/4885DPP8 28/4885
US-20140018371-A1 Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto GPR119, GCGR, GLP1R DPP4 9/4885FAP 799/4885DPP8 48/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.