Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DAPK3 | O43293 | 5/20 | 0.55 |
| ▸ | PIM1 | P11309 | 5/20 | 0.55 |
| ▸ | GSK3A | P49840 | 5/20 | 0.55 |
| ▸ | GSK3B | P49841 | 5/20 | 0.55 |
| ▸ | PLK4 | O00444 | 4/20 | 0.55 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.55 |
| ▸ | CDK1 | P06493 | 4/20 | 0.55 |
| ▸ | CDK2 | P24941 | 4/20 | 0.55 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.55 |
| ▸ | CSNK1D | P48730 | 4/20 | 0.55 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.55 |
| ▸ | PLK3 | Q9H4B4 | 4/20 | 0.55 |
| ▸ | PRKACA | P17612 | 4/20 | 0.55 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.55 |
| ▸ | AURKA | O14965 | 3/20 | 0.55 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.55 |
| ▸ | SGK2 | Q9HBY8 | 3/20 | 0.55 |
| ▸ | MAP3K8 | P41279 | 5/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553864 | 0.85 | ICAM1 (0.53) | DAPK3PIM1GSK3AGSK3BPLK4 | |
| SCHEMBL7051862 | 0.80 | PLK4 (0.60) | DAPK3PIM1GSK3AGSK3BPLK4 | |
| SCHEMBL7051866 | 0.80 | PLK4 (0.60) | DAPK3PIM1GSK3AGSK3BPLK4 | |
| SCHEMBL660382 | 0.77 | GSK3A (0.60) | DAPK3PIM1GSK3AGSK3BPLK4 | |
| SCHEMBL24721595 | 0.76 | PLK4 (0.59) | DAPK3PIM1GSK3AGSK3BPLK4 | |
| SCHEMBL658705 | 0.76 | ICAM1 (0.73) | DAPK3PIM1GSK3AGSK3BPLK4 | |
| SCHEMBL15910879 | 0.76 | PIM1 (0.59) | DAPK3PIM1GSK3AGSK3BPLK4 | |
| SCHEMBL7619323 | 0.71 | GSK3A (1.00) | DAPK3PIM1GSK3AGSK3BPLK4 | |
| SCHEMBL7056216 | 0.69 | PIM1 (0.62) | DAPK3PIM1GSK3AGSK3BPLK4 | |
| SCHEMBL7056218 | 0.69 | PIM1 (0.62) | DAPK3PIM1GSK3AGSK3BPLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753428-A2 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | Abbott Laboratories (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005110410-A2 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | ABBOTT LABORATORIES (US) | 2005-11-24 | — | — | WO | disclosed |