Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 3/20 | 0.60 |
| ▸ | AURKA | O14965 | 3/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.60 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.60 |
| ▸ | CDK1 | P06493 | 3/20 | 0.60 |
| ▸ | PIM1 | P11309 | 3/20 | 0.60 |
| ▸ | CDK2 | P24941 | 3/20 | 0.60 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.60 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.60 |
| ▸ | GSK3A | P49840 | 3/20 | 0.60 |
| ▸ | GSK3B | P49841 | 3/20 | 0.60 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.60 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.60 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.60 |
| ▸ | PRKACA | P17612 | 2/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.60 |
| ▸ | SGK2 | Q9HBY8 | 2/20 | 0.60 |
| ▸ | MAP3K8 | P41279 | 6/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7051862 | 1.00 | PLK4 (0.60) | PLK4AURKADAPK3CHEK2CDK1 | |
| SCHEMBL7056216 | 0.89 | PIM1 (0.62) | PLK4AURKADAPK3CHEK2CDK1 | |
| SCHEMBL7056218 | 0.89 | PIM1 (0.62) | PLK4AURKADAPK3CHEK2CDK1 | |
| SCHEMBL5550116 | 0.80 | DAPK3 (0.55) | PLK4AURKADAPK3CHEK2CDK1 | |
| SCHEMBL7619323 | 0.75 | GSK3A (1.00) | PLK4AURKADAPK3CHEK2CDK1 | |
| SCHEMBL5550715 | 0.72 | MAP3K8 (0.85) | PLK4AURKADAPK3CHEK2CDK1 | |
| SCHEMBL9431528 | 0.72 | HDAC3 (0.47) | CSNK1DGSK3AGSK3BCSNK2A1DYRK1A | |
| SCHEMBL31390717 | 0.71 | PLK4 (0.59) | PLK4AURKADAPK3CHEK2CDK1 | |
| SCHEMBL24721595 | 0.71 | PLK4 (0.59) | PLK4AURKADAPK3CHEK2CDK1 | |
| SCHEMBL658705 | 0.71 | ICAM1 (0.73) | PLK4AURKADAPK3CHEK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220365-A1 | Cell adhesion-inhibiting antiinflammatory compounds | STEWART ANDREW O (US) | 2003-11-27 | — | — | US | disclosed |
| US-6579882-B2 | Thieno(2,3-d)pyrimidine derivatives | ABBOTT LABORATORIES | 2003-06-17 | — | — | US | disclosed |
| US-20010020030-A1 | Cell adhesion-inhibiting antiinflammatory compounds | ABBVIE INC. | 2001-09-06 | — | — | US | disclosed |
| US-6232320-B1 | THIENO(2,3-C)PYRIDINE AND 5H-THIENO(2,3-C)PYRAN DERIATIVES | ABBOTT LABORATORIES | 2001-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020030-A1 | Cell adhesion-inhibiting antiinflammatory compounds | ICAM1, VCAM1, EPCAM | PLK4 4107/4885AURKA 4748/4885DAPK3 1000/4885 |
| US-20030220365-A1 | Cell adhesion-inhibiting antiinflammatory compounds | ICAM1, VCAM1, EPCAM | PLK4 4107/4885AURKA 4748/4885DAPK3 1000/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.