Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 6/20 | 0.60 |
| ▸ | GSK3A | P49840 | 6/20 | 0.60 |
| ▸ | GSK3B | P49841 | 6/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.60 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.60 |
| ▸ | PRKACA | P17612 | 5/20 | 0.60 |
| ▸ | RPS6KA3 | P51812 | 5/20 | 0.60 |
| ▸ | KDR | P35968 | 5/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 5/20 | 0.60 |
| ▸ | LIMK1 | P53667 | 5/20 | 0.60 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.60 |
| ▸ | CLK2 | P49760 | 3/20 | 0.60 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.60 |
| ▸ | FLT1 | P17948 | 3/20 | 0.60 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.60 |
| ▸ | LTK | P29376 | 1/20 | 0.60 |
| ▸ | GRK5 | P34947 | 1/20 | 0.60 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554072 | 0.82 | MAP3K8 (0.74) | PIM1GSK3AGSK3BCDK5ROCK1 | |
| SCHEMBL7055380 | 0.75 | PIM1 (1.00) | PIM1GSK3AGSK3BCDK5ROCK1 | |
| SCHEMBL742713 | 0.72 | ICAM1 (0.67) | PIM1GSK3AGSK3BCDK5ROCK1 | |
| SCHEMBL30568694 | 0.72 | ICAM1 (0.67) | PIM1GSK3AGSK3BCDK5ROCK1 | |
| SCHEMBL6437155 | 0.72 | ICAM1 (1.00) | PIM1GSK3AGSK3BCDK5ROCK1 | |
| SCHEMBL7056150 | 0.72 | ICAM1 (1.00) | PIM1GSK3AGSK3BCDK5ROCK1 | |
| SCHEMBL5550182 | 0.71 | MAP3K8 (0.76) | PIM1GSK3AGSK3BCDK5ROCK1 | |
| SCHEMBL5550309 | 0.71 | PIM1 (0.61) | PIM1GSK3AGSK3BCDK5ROCK1 | |
| SCHEMBL7054697 | 0.70 | ICAM1 (1.00) | PIM1GSK3AGSK3BCDK5ROCK1 | |
| SCHEMBL5550743 | 0.68 | MAP3K8 (1.00) | PIM1GSK3AGSK3BCDK5ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753428-A2 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | Abbott Laboratories (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20060074102-A1 | Kinase inhibitors as therapeutic agents | ABBOTT LABORATORIES | 2006-04-06 | — | — | US | disclosed |
| WO-2005110410-A2 | KINASE INHIBITORS AS THERAPEUTIC AGENTS | ABBOTT LABORATORIES (US) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060074102-A1 | Kinase inhibitors as therapeutic agents | ABL1, MAP3K19, MAP3K20 | PIM1 252/4885GSK3A 453/4885GSK3B 462/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.