Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 15/20 | 1.00 |
| ▸ | SELE | P16581 | 15/20 | 1.00 |
| ▸ | VCAM1 | P19320 | 5/20 | 1.00 |
| ▸ | PIM1 | P11309 | 6/20 | 0.59 |
| ▸ | GSK3A | P49840 | 6/20 | 0.59 |
| ▸ | GSK3B | P49841 | 6/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 6/20 | 0.59 |
| ▸ | PRKACA | P17612 | 5/20 | 0.59 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.59 |
| ▸ | DAPK3 | O43293 | 4/20 | 0.59 |
| ▸ | KDR | P35968 | 4/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.59 |
| ▸ | LIMK1 | P53667 | 4/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.59 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.59 |
| ▸ | CLK2 | P49760 | 3/20 | 0.59 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.59 |
| ▸ | CDK8 | P49336 | 2/20 | 0.59 |
| ▸ | CDK9 | P50750 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL658705 | 0.85 | ICAM1 (0.73) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL29069393 | 0.81 | ICAM1 (0.69) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL15518133 | 0.80 | ICAM1 (0.67) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL30568694 | 0.80 | ICAM1 (0.67) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL14023789 | 0.80 | ICAM1 (0.67) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL742713 | 0.80 | ICAM1 (0.67) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL1594381 | 0.80 | ICAM1 (0.66) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL660279 | 0.80 | ICAM1 (0.66) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL30744193 | 0.80 | ICAM1 (0.66) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL7053404 | 0.79 | PIM1 (0.69) | ICAM1SELEVCAM1PIM1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030220365-A1 | Cell adhesion-inhibiting antiinflammatory compounds | STEWART ANDREW O (US) | 2003-11-27 | — | — | US | claimed |
| EP-1181296-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY COMPOUNDS | ABBOTT LABORATORIES (US) | 2002-02-27 | — | — | EP | claimed |
| US-20010020030-A1 | Cell adhesion-inhibiting antiinflammatory compounds | ABBVIE INC. | 2001-09-06 | — | — | US | claimed |
| EP-1090009-A2 | CELL ADHESION-INHIBITING ANTINFLAMMATORY COMPOUNDS | ABBOTT LABORATORIES (US) | 2001-04-11 | — | — | EP | claimed |
| WO-2000075145-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-12-14 | — | — | WO | claimed |
| WO-1999062908-A2 | CELL ADHESION-INHIBITING ANTINFLAMMATORY COMPOUNDS | ABBOTT LABORATORIES (US) | 1999-12-09 | — | — | WO | claimed |
| US-10154992-B2 | Compounds and methods for treating HIV infection | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-12-18 | — | — | US | disclosed |
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | NAKAMURA, ROBERT | 2018-01-18 | — | — | US | disclosed |
| US-20030220365-A1 | Cell adhesion-inhibiting antiinflammatory compounds | STEWART ANDREW O (US) | 2003-11-27 | — | — | US | disclosed |
| US-6579882-B2 | Thieno(2,3-d)pyrimidine derivatives | ABBOTT LABORATORIES | 2003-06-17 | — | — | US | disclosed |
| EP-1181296-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY COMPOUNDS | ABBOTT LABORATORIES (US) | 2002-02-27 | — | — | EP | disclosed |
| US-20010020030-A1 | Cell adhesion-inhibiting antiinflammatory compounds | ABBVIE INC. | 2001-09-06 | — | — | US | disclosed |
| US-6232320-B1 | THIENO(2,3-C)PYRIDINE AND 5H-THIENO(2,3-C)PYRAN DERIATIVES | ABBOTT LABORATORIES | 2001-05-15 | — | — | US | disclosed |
| WO-2000075145-A1 | CELL ADHESION-INHIBITING ANTIINFLAMMATORY COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-12-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010020030-A1 | Cell adhesion-inhibiting antiinflammatory compounds | ICAM1, VCAM1, EPCAM | ICAM1 1/4885SELE 16/4885VCAM1 2/4885 |
| US-10154992-B2 | Compounds and methods for treating HIV infection | CD4, CCR5, MMP8 | ICAM1 65/4885SELE 751/4885VCAM1 422/4885 |
| US-20030220365-A1 | Cell adhesion-inhibiting antiinflammatory compounds | ICAM1, VCAM1, EPCAM | ICAM1 1/4885SELE 16/4885VCAM1 2/4885 |
| US-20180015077-A1 | COMPOUNDS AND METHODS FOR TREATING HIV INFECTION | CD4, CCR5, MMP8 | ICAM1 65/4885SELE 751/4885VCAM1 422/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.