Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.58 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.50 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | NCF1 | P14598 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5547096 | 0.87 | KDM4E (0.48) | LOXL2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL14650799 | 0.81 | LOXL2 (0.58) | LOXL2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL1253989 | 0.81 | LOXL2 (0.58) | LOXL2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL28879838 | 0.81 | LOXL2 (0.63) | LOXL2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL31599195 | 0.79 | LOXL2 (0.67) | LOXL2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL334360 | 0.79 | LOXL2 (0.67) | LOXL2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL5549788 | 0.79 | KDM4E (0.39) | LOXL2CYP1A2ALDH1A1LMNAKDM4E | |
| SCHEMBL2937018 | 0.79 | CYP1A2 (0.54) | LOXL2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL269209 | 0.78 | LOXL2 (0.55) | LOXL2HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL1040581 | 0.78 | LOXL2 (0.55) | LOXL2HTR1AADRA1DADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1830858-A2 | 3, 6-BICYCLOLIDES | Enanta Pharmaceuticals, Inc. (US) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006063039-A2 | 3, 6-BICYCLOLIDES | ENANTA PHARMACEUTICALS, INC. (US) | 2006-06-15 | — | — | WO | disclosed |