Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | APLNR | P35414 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | BLM | P54132 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | CAD | P27708 | 2/20 | 0.34 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1973599 | 1.00 | HTT (0.55) | HTTKMT2AAPLNRCYP2D6LMNA | |
| SCHEMBL18576561 | 0.82 | HTT (0.53) | HTTKMT2AAPLNRCYP2D6LMNA | |
| SCHEMBL10137633 | 0.79 | KMT2A (0.58) | HTTKMT2ACYP2D6ALOX15CYP1A2 | |
| SCHEMBL25414098 | 0.75 | HTT (0.46) | HTTKMT2ACYP2D6LMNABLM | |
| SCHEMBL19585894 | 0.75 | HTT (0.46) | HTTKMT2ACYP2D6LMNABLM | |
| SCHEMBL25414095 | 0.75 | HTT (0.46) | HTTKMT2ACYP2D6LMNABLM | |
| SCHEMBL7551520 | 0.75 | HTT (0.46) | HTTKMT2ACYP2D6LMNABLM | |
| SCHEMBL7455295 | 0.75 | HTT (0.46) | HTTKMT2ACYP2D6LMNABLM | |
| Limazocic SCHEMBL9329801 | 0.74 | HTT (0.58) | HTTKMT2ACADMAPTITGA4 | |
| Limazocic SCHEMBL9326335 | 0.74 | HTT (0.58) | HTTKMT2ACADMAPTITGA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017189866-A1 | POLYMYXIN ANALOGS USEFUL AS ANTIBIOTIC POTENTIATORS | SPERO OPCO (US) | 2017-11-02 | — | — | WO | disclosed |
| EP-1481000-B1 | NOVEL PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |
| EP-1385870-B1 | PEPTIDES AS NS3-SERINE PROTEASE INHIBITORS OF HEPATITIS C VIRUS | SCHERING CORP (US) | 2010-03-17 | — | — | EP | disclosed |
| EP-1593682-B1 | Derivatives of 4-oxo-4,6,7,8-tetrahydropyrrolo¬1,2-a pyrazine-6-carboxamides, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2007-11-07 | — | — | EP | disclosed |
| EP-1593682-A2 | Derivatives of 4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrazine-6-carboxamides, process for their preparation and pharmaceutical compositions thereof | LES LABORATOIRES SERVIER (FR) | 2005-11-09 | — | — | EP | disclosed |