Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 7/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | CNR2 | P34972 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 4/20 | 0.35 |
| ▸ | CNR1 | P21554 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | ABHD12 | Q8N2K0 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8302740 | 0.88 | PDE4B (0.46) | PDE4BPDE4APDE4DHPGDCNR2 | |
| SCHEMBL8303135 | 0.88 | PDE4B (0.44) | PDE4BPDE4APDE4DHPGDTYK2 | |
| SCHEMBL4187279 | 0.88 | PDE4B (0.44) | PDE4BPDE4APDE4DHPGDTYK2 | |
| Hydrochloric Acid SCHEMBL4185098 | 0.87 | PDE4B (0.44) | PDE4BPDE4APDE4DHPGDTYK2 | |
| SCHEMBL4187275 | 0.86 | PDE4B (0.43) | PDE4BPDE4APDE4DHPGDCNR2 | |
| SCHEMBL5547933 | 0.85 | PDE4B (0.55) | PDE4BPDE4APDE4DHPGDCNR2 | |
| SCHEMBL8303245 | 0.85 | PDE4B (0.50) | PDE4BPDE4APDE4DHPGDCNR2 | |
| SCHEMBL4182884 | 0.85 | PDE4B (0.50) | PDE4BPDE4APDE4DHPGDCNR2 | |
| SCHEMBL13929105 | 0.85 | PDE4B (0.50) | PDE4BPDE4APDE4DHPGDCNR2 | |
| SCHEMBL8301516 | 0.84 | PDE4B (0.43) | PDE4BPDE4APDE4DCNR2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1651641-B1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LTD (GB) | 2007-05-23 | — | — | EP | disclosed |