Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.81 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CA4 | P22748 | 1/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9312694 | 0.91 | POLB (0.67) | POLBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL9429642 | 0.90 | POLB (1.00) | POLBMAPTTSHRHDAC3HDAC4 | |
| SCHEMBL7057797 | 0.88 | POLB (0.91) | POLBCA1CA2NPC1RAB9A | |
| SCHEMBL13239485 | 0.87 | POLB (0.88) | POLBCA1CA2NPC1RAB9A | |
| SCHEMBL7056819 | 0.87 | POLB (0.88) | POLBCA1CA2NPC1RAB9A | |
| SCHEMBL11983728 | 0.86 | POLB (0.71) | POLBMAPTTSHRHDAC3HDAC4 | |
| SCHEMBL17874906 | 0.86 | POLB (0.61) | POLBHDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL10117151 | 0.85 | POLB (0.60) | POLBMAPTHDAC3HDAC4HDAC1 | |
| SCHEMBL7055067 | 0.85 | POLB (0.70) | POLBMAPTTSHRHDAC3HDAC4 | |
| SCHEMBL593172 | 0.84 | MAPT (0.74) | POLBMAPTTSHRCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1742924-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-01-17 | — | — | EP | disclosed |
| WO-2005108376-A1 | CALCILYTIC COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-11-17 | — | — | WO | disclosed |