Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | KDM1A | O60341 | 7/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2257197 | 0.79 | EGFR (0.67) | EGFRPDGFRBKDRKDM1AHDAC1 | |
| SCHEMBL5553089 | 0.70 | EGFR (0.66) | EGFRPDGFRBKDRMERTKADORA2A | |
| SCHEMBL18235115 | 0.68 | ADORA2A (0.50) | ADORA2AKDM4ELMNAMAPTTSHR | |
| SCHEMBL29985983 | 0.68 | ADORA2A (0.50) | ADORA2AKDM4ELMNAHPGD | |
| SCHEMBL16542822 | 0.68 | ADORA2A (0.50) | ADORA2AKDM4ELMNAHPGD | |
| SCHEMBL20474529 | 0.67 | NR3C2 (0.58) | EGFRPDGFRBKDRKDM1AMERTK | |
| SCHEMBL2258926 | 0.65 | EGFR (0.61) | EGFRPDGFRBKDRHDAC1HDAC8 | |
| SCHEMBL3113560 | 0.65 | EGFR (0.49) | EGFRPDGFRBKDRHDAC1HDAC8 | |
| SCHEMBL19789164 | 0.65 | EGFR (0.74) | EGFRPDGFRBKDRHDAC1HDAC8 | |
| SCHEMBL3115859 | 0.65 | EGFR (0.74) | EGFRPDGFRBKDRHDAC1HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833511-A2 | METHOD OF TREATING BRAIN CANCER | MYRIAD GENETICS, INC. (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006074187-A2 | METHOD OF TREATING BRAIN CANCER | MYRIAD GENETICS, INC. (US) | 2006-07-13 | — | — | WO | disclosed |