Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.66 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.66 |
| ▸ | KDR | P35968 | 2/20 | 0.66 |
| ▸ | MERTK | Q12866 | 3/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.46 |
| ▸ | CASP14 | P31944 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | CASP2 | P42575 | 1/20 | 0.46 |
| ▸ | CASP4 | P49662 | 1/20 | 0.46 |
| ▸ | CASP5 | P51878 | 1/20 | 0.46 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | CASP9 | P55211 | 1/20 | 0.46 |
| ▸ | CASP6 | P55212 | 1/20 | 0.46 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.46 |
| ▸ | CASP12 | Q6UXS9 | 1/20 | 0.46 |
| ▸ | CASP10 | Q92851 | 1/20 | 0.46 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.46 |
| ▸ | TUBB | P07437 | 2/20 | 0.46 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.46 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553119 | 0.84 | EGFR (0.46) | EGFRPDGFRBKDRADORA2A | |
| SCHEMBL2257339 | 0.80 | EGFR (1.00) | EGFRPDGFRBKDRMERTKCASP1 | |
| Hydrochloric Acid SCHEMBL1685084 | 0.79 | EGFR (0.97) | EGFRPDGFRBKDRMERTKCASP1 | |
| SCHEMBL5559424 | 0.77 | USP2 (0.46) | EGFRPDGFRBKDRLMNA | |
| SCHEMBL6778392 | 0.73 | CES1 (0.49) | EGFRPDGFRBKDRMERTKCASP1 | |
| SCHEMBL12048740 | 0.70 | EGFR (0.51) | EGFRPDGFRBKDRMERTKCASP1 | |
| SCHEMBL28563328 | 0.70 | ABL1 (0.50) | EGFRPDGFRBKDRLMNAHPGD | |
| SCHEMBL3118902 | 0.70 | EGFR (0.75) | EGFRPDGFRBKDRMERTKCASP1 | |
| SCHEMBL5552958 | 0.70 | EGFR (0.43) | EGFRPDGFRBKDRMERTKLMNA | |
| SCHEMBL3108888 | 0.69 | EGFR (0.76) | EGFRPDGFRBKDRTUBB4ATUBB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833511-A2 | METHOD OF TREATING BRAIN CANCER | MYRIAD GENETICS, INC. (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006074187-A2 | METHOD OF TREATING BRAIN CANCER | MYRIAD GENETICS, INC. (US) | 2006-07-13 | — | — | WO | disclosed |