Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FES | P07332 | 1/20 | 0.58 |
| ▸ | RET | P07949 | 1/20 | 0.58 |
| ▸ | MARK3 | P27448 | 1/20 | 0.58 |
| ▸ | TYK2 | P29597 | 1/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.58 |
| ▸ | SYK | P43405 | 1/20 | 0.58 |
| ▸ | CLK2 | P49760 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | NAMPT | P43490 | 6/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5557339 | 0.86 | FES (0.61) | FESRETMARK3TYK2FLT4 | |
| SCHEMBL5557494 | 0.77 | FES (0.76) | FESRETMARK3TYK2FLT4 | |
| SCHEMBL18317996 | 0.76 | FLT4 (1.00) | FESRETMARK3TYK2FLT4 | |
| SCHEMBL1514550 | 0.76 | FLT4 (1.00) | FESRETMARK3TYK2FLT4 | |
| SCHEMBL18317166 | 0.76 | FLT4 (1.00) | FESRETMARK3TYK2FLT4 | |
| SCHEMBL18317214 | 0.76 | FLT4 (1.00) | FESRETMARK3TYK2FLT4 | |
| SCHEMBL18317601 | 0.76 | FLT4 (1.00) | FESRETMARK3TYK2FLT4 | |
| SCHEMBL18317546 | 0.76 | FLT4 (1.00) | FESRETMARK3TYK2FLT4 | |
| SCHEMBL18317211 | 0.76 | FLT4 (1.00) | FESRETMARK3TYK2FLT4 | |
| SCHEMBL18317181 | 0.76 | FLT4 (1.00) | FESRETMARK3TYK2FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1154998-B1 | INHIBITORS OF CELLULAR NIACINAMIDE MONONUCLEOTIDE FORMATION AND THEIR USE IN CANCER THERAPY | ASTELLAS DEUTSCHLAND GMBH (DE) | 2007-09-26 | — | — | EP | claimed |