Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 2/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.39 |
| ▸ | TUBB | P07437 | 1/20 | 0.39 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.39 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.39 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.39 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.39 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.39 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553117 | 0.84 | EGFR (0.34) | EGFRPDGFRBKDRTUBB4ATUBB | |
| SCHEMBL1685039 | 0.80 | EGFR (0.52) | EGFRPDGFRBKDRADORA2ACYP1A2 | |
| Hydrochloric Acid SCHEMBL1685079 | 0.79 | EGFR (0.51) | EGFRPDGFRBKDRADORA2ACYP1A2 | |
| SCHEMBL5559420 | 0.76 | EDNRA (0.47) | CYP1A2CYP2C9CYP2C19KMT2ATP53 | |
| SCHEMBL3119434 | 0.73 | MEN1 (0.45) | EGFRPDGFRBKDRGAATUBB4A | |
| SCHEMBL3113186 | 0.72 | EGFR (0.49) | EGFRPDGFRBKDRADORA2ACYP1A2 | |
| SCHEMBL3113281 | 0.71 | ADORA2A (0.42) | EGFRPDGFRBKDRADORA2APOLB | |
| SCHEMBL3110824 | 0.71 | EGFR (0.44) | EGFRPDGFRBKDRGAATUBB4A | |
| SCHEMBL5552956 | 0.71 | KDM1A (0.41) | CYP1A2GAAPOLBAPPKDM1A | |
| SCHEMBL3106572 | 0.70 | KDM4E (0.46) | CYP1A2GAAPOLBCYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833511-A2 | METHOD OF TREATING BRAIN CANCER | MYRIAD GENETICS, INC. (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006074187-A2 | METHOD OF TREATING BRAIN CANCER | MYRIAD GENETICS, INC. (US) | 2006-07-13 | — | — | WO | disclosed |