Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | ACP1 | P24666 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5553085 | 0.84 | EGFR (0.46) | EGFRPDGFRBKDRKMT2AKDM1A | |
| SCHEMBL3110678 | 0.82 | EGFR (0.38) | EGFRPDGFRBKDRGBA1ACP1 | |
| SCHEMBL5559420 | 0.72 | EDNRA (0.47) | KMT2AMEN1USP2 | |
| SCHEMBL3122392 | 0.69 | KRAS (0.38) | EGFRPDGFRBKDRACP1KMT2A | |
| SCHEMBL19806090 | 0.68 | KDM4E (0.58) | EGFRPDGFRBKDRACP1KMT2A | |
| SCHEMBL3113281 | 0.68 | ADORA2A (0.42) | EGFRPDGFRBKDRKMT2AALDH1A1 | |
| SCHEMBL1685039 | 0.67 | EGFR (0.52) | EGFRPDGFRBKDRKMT2AKDM1A | |
| SCHEMBL3118700 | 0.67 | NUDT1 (0.40) | ACP1KMT2AMEN1USP2KDM1A | |
| SCHEMBL3110407 | 0.67 | KDM1A (0.41) | ACP1KMT2AMEN1USP2KDM1A | |
| Hydrochloric Acid SCHEMBL1685079 | 0.66 | EGFR (0.51) | EGFRPDGFRBKDRKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833511-A2 | METHOD OF TREATING BRAIN CANCER | MYRIAD GENETICS, INC. (US) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006074187-A2 | METHOD OF TREATING BRAIN CANCER | MYRIAD GENETICS, INC. (US) | 2006-07-13 | — | — | WO | disclosed |