Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GALR1 | P47211 | 4/20 | 0.53 |
| ▸ | ENO1 | P06733 | 1/20 | 0.39 |
| ▸ | GALR2 | O43603 | 4/20 | 0.37 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.36 |
| ▸ | AXL | P30530 | 3/20 | 0.35 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | MET | P08581 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4837659 | 0.99 | GALR1 (0.54) | GALR1ENO1GALR2PI4KBAXL | |
| Hydrochloric Acid SCHEMBL5549836 | 0.92 | GALR1 (0.44) | GALR1GALR2AXLEGFR | |
| SCHEMBL5549426 | 0.91 | GALR1 (0.45) | GALR1GALR2AXLEGFR | |
| SCHEMBL4837656 | 0.89 | GALR1 (0.43) | GALR1GALR2AXL | |
| SCHEMBL4836927 | 0.87 | GALR1 (0.58) | GALR1ENO1GALR2PI4KB | |
| Hydrochloric Acid SCHEMBL5031332 | 0.87 | GALR1 (0.58) | GALR1ENO1GALR2PI4KB | |
| SCHEMBL5550501 | 0.83 | GALR1 (0.49) | GALR1ENO1GALR2PI4KBAXL | |
| SCHEMBL5431447 | 0.80 | GALR1 (0.67) | GALR1ENO1GALR2PI4KB | |
| SCHEMBL4838906 | 0.80 | GALR1 (0.61) | GALR1ENO1GALR2PI4KB | |
| SCHEMBL4838523 | 0.79 | GALR1 (0.48) | GALR1GALR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7238692-B2 | Medical devices employing triazine compounds and compositions thereof | REDDY US THERAPEUTICS, INC. (US) | 2007-07-03 | — | — | US | disclosed |
| US-7169785-B2 | Methods and compositions of novel triazine compounds | REDDY US THERAPEUTICS, INC. (US) | 2007-01-30 | — | — | US | disclosed |