Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560536 | 0.79 | KMT2A (0.36) | AKR1C3AKR1C2KMT2AMEN1CES2 | |
| SCHEMBL5814619 | 0.79 | CNR1 (0.38) | ALDH1A1SMN1; SMN2ELANEAKR1C3AKR1C2 | |
| SCHEMBL5554426 | 0.78 | LMNA (0.42) | LMNAALDH1A1PLA2G7SMN1; SMN2ELANE | |
| SCHEMBL5553721 | 0.78 | AKR1C3 (0.44) | LMNAALDH1A1PLA2G7SMN1; SMN2ELANE | |
| SCHEMBL5561193 | 0.77 | HPGD (0.34) | LMNAALDH1A1ELANEAKR1C3AKR1C2 | |
| SCHEMBL5554202 | 0.77 | TACR3 (0.33) | AKR1C3AKR1C2 | |
| SCHEMBL5559390 | 0.77 | AKR1C3 (0.42) | LMNAAKR1C3AKR1C2KMT2AMEN1 | |
| SCHEMBL5559414 | 0.77 | LMNA (0.40) | LMNAALDH1A1PLA2G7SMN1; SMN2ELANE | |
| SCHEMBL5560599 | 0.75 | LMNA (0.39) | LMNAALDH1A1PLA2G7SMN1; SMN2ELANE | |
| SCHEMBL5814353 | 0.75 | LMNA (0.36) | LMNAALDH1A1PLA2G7SMN1; SMN2ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |