⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3186066 | 1.00 | — | — | |
| SCHEMBL3370694 | 1.00 | — | — | |
| Trifluoroacetic Acid SCHEMBL6511645 | 0.87 | DPP8 (0.33) | — | |
| SCHEMBL27517629 | 0.78 | CA1 (0.46) | — | |
| SCHEMBL10822864 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL10822867 | 0.77 | CYP2D6 (0.34) | — | |
| SCHEMBL27730236 | 0.77 | TDP1 (0.35) | — | |
| SCHEMBL27540661 | 0.77 | ACE2 (0.44) | — | |
| SCHEMBL4770945 | 0.75 | — | — | |
| SCHEMBL20030568 | 0.74 | PIK3CD (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594854-A4 | THIAZOLYL-BASED COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2007-07-18 | — | — | EP | disclosed |
| EP-1711481-A2 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2006-10-18 | — | — | EP | disclosed |
| EP-1594854-A2 | THIAZOLYL-BASED COMPOUNDS USEFUL AS KINASE INHIBITORS | Bristol-Myers Squibb Company (US) | 2005-11-16 | — | — | EP | disclosed |
| WO-2005077945-A2 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-AROMATIC CARBOXAMIDES AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-08-25 | — | — | WO | disclosed |
| WO-2005076990-A2 | PROCESS FOR PREPARING 2-AMINOTHIAZOLE-5-CARBOXAMIDES USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-08-25 | — | — | WO | disclosed |
| WO-2004071440-A2 | THIAZOLYL-BASED COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-08-26 | — | — | WO | disclosed |