Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.37 |
| ▸ | PPARA | Q07869 | 4/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 3/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5560242 | 0.86 | PPARG (0.37) | PPARGPPARAAKR1C3AKR1C2 | |
| SCHEMBL5799149 | 0.85 | AKR1C3 (0.43) | PPARGAKR1C3AKR1C2 | |
| SCHEMBL5560554 | 0.84 | HRH3 (0.40) | PPARGPPARAAKR1C3AKR1C2HRH3 | |
| SCHEMBL5559277 | 0.84 | SCN9A (0.37) | PPARGPPARAHRH3HSD11B1 | |
| SCHEMBL5559328 | 0.84 | HRH3 (0.40) | PPARGPPARAAKR1C3AKR1C2HRH3 | |
| SCHEMBL5553908 | 0.81 | PPARG (0.36) | PPARGPPARAAKR1C3AKR1C2HRH3 | |
| SCHEMBL5553805 | 0.80 | HRH3 (0.35) | PPARGAKR1C3AKR1C2HRH3HSD11B1 | |
| SCHEMBL6423914 | 0.80 | PPARG (0.42) | PPARGPPARAAKR1C3AKR1C2HRH3 | |
| SCHEMBL5554448 | 0.80 | AKR1C3 (0.54) | PPARGAKR1C3AKR1C2 | |
| SCHEMBL5558979 | 0.80 | AKR1C3 (0.39) | PPARGPPARAAKR1C3AKR1C2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |