Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 11/20 | 0.39 |
| ▸ | PPARA | Q07869 | 5/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.35 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.35 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5559328 | 1.00 | HRH3 (0.40) | HRH3PPARGPPARAEPHX2AKR1C3 | |
| SCHEMBL5558544 | 0.88 | PTGS2 (0.34) | PPARGPPARAAKR1C3AKR1C2PTGS2 | |
| SCHEMBL5560462 | 0.88 | PTGS2 (0.34) | PPARGPPARAAKR1C3AKR1C2PTGS2 | |
| SCHEMBL5798576 | 0.86 | PTGS2 (0.41) | PPARGAKR1C3AKR1C2PTGS2 | |
| SCHEMBL5554254 | 0.86 | PTGS2 (0.34) | AKR1C3AKR1C2PTGS2 | |
| SCHEMBL5554445 | 0.84 | PPARG (0.37) | HRH3PPARGPPARAAKR1C3AKR1C2 | |
| SCHEMBL5560446 | 0.82 | HRH3 (0.39) | HRH3PPARGPPARAEPHX2TRPV1 | |
| SCHEMBL5560599 | 0.81 | LMNA (0.39) | AKR1C3AKR1C2 | |
| SCHEMBL5560527 | 0.81 | PTGS2 (0.33) | AKR1C3AKR1C2PTGS2 | |
| SCHEMBL5559277 | 0.78 | SCN9A (0.37) | HRH3PPARGPPARATRPV1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |