Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5554698 | 0.86 | PTGS2 (0.55) | PTGS2AKR1C3AKR1C2PTGS1HTR1A | |
| SCHEMBL5554695 | 0.86 | AKR1C3 (0.59) | PTGS2AKR1C3AKR1C2PTGS1GLO1 | |
| SCHEMBL6423743 | 0.83 | PTGS2 (0.46) | PTGS2AKR1C3AKR1C2PTGS1GLO1 | |
| SCHEMBL5814349 | 0.80 | PTGS2 (0.45) | PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL5814350 | 0.80 | PTGS2 (0.45) | PTGS2AKR1C3AKR1C2PTGS1 | |
| SCHEMBL2000986 | 0.80 | AKR1C3 (0.72) | PTGS2AKR1C3AKR1C2PTGS1HTR1A | |
| SCHEMBL5797344 | 0.80 | PTGS2 (0.53) | PTGS2AKR1C3AKR1C2PTGS1HTR1A | |
| SCHEMBL5800814 | 0.79 | AKR1C3 (0.48) | PTGS2AKR1C3AKR1C2PTGS1GLO1 | |
| SCHEMBL5558176 | 0.79 | PTGS2 (0.64) | PTGS2AKR1C3CNR2AKR1C2PTGS1 | |
| SCHEMBL5559410 | 0.78 | PTGS2 (0.58) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |