Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.42 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
| ▸ | CDC7 | O00311 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | USP19 | O94966 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5559518 | 0.96 | GSK3B (0.43) | GSK3BPIK3R1PIK3CACDC7ROCK2 | |
| SCHEMBL5554219 | 0.90 | GSK3B (0.39) | GSK3BPIK3R1PIK3CAKDM4EALDH1A1 | |
| SCHEMBL4416870 | 0.89 | KDM4E (0.43) | GSK3BPIK3R1PIK3CACDC7ROCK2 | |
| SCHEMBL4416876 | 0.89 | KDM4E (0.43) | GSK3BPIK3R1PIK3CACDC7ROCK2 | |
| SCHEMBL5554458 | 0.88 | GSK3B (0.40) | GSK3BCDC7ROCK2PIM1HIPK2 | |
| SCHEMBL4429669 | 0.87 | KDM4E (0.47) | GSK3BCDC7ROCK2PIM1HIPK2 | |
| SCHEMBL5558728 | 0.86 | GSK3B (0.39) | GSK3BPIK3R1PIK3CACDC7ROCK2 | |
| SCHEMBL5559159 | 0.86 | GSK3B (0.40) | GSK3BKDM4EALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL5560969 | 0.84 | GSK3B (0.41) | GSK3BCDC7ROCK2PIM1HIPK2 | |
| SCHEMBL4423179 | 0.84 | GSK3B (0.50) | GSK3BPIK3R1PIK3CACDC7ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1699795-B1 | SUBSTITUTED 8'-PYRI(MI)DINYL-DIHYDROSPIRO-[CYCLOALKLYMINE]-PYRIMIDO[1,2A]PYRIMIDIN-6-ONE DERIVATIVES | SANOFI AVENTIS (FR) | 2007-04-25 | — | — | EP | claimed |