Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.60 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | GAA | P10253 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10135139 | 0.89 | ALDH1A1 (0.61) | ALDH1A1GRIN2CKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL6317837 | 0.84 | ALDH1A1 (0.60) | ALDH1A1GRIN2CKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13431200 | 0.81 | ALDH1A1 (0.66) | ALDH1A1GRIN2CKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL13431179 | 0.80 | ALDH1A1 (0.53) | ALDH1A1GRIN2CKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5555718 | 0.79 | ALDH1A1 (0.62) | ALDH1A1GRIN2CKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL3083629 | 0.78 | IKBKB (0.50) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL2759478 | 0.76 | ALDH1A1 (0.59) | ALDH1A1KMT2AMEN1SMN1; SMN2MAPT | |
| SCHEMBL7906323 | 0.75 | GRIN2C (1.00) | ALDH1A1GRIN2CKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL5556399 | 0.75 | IKBKB (0.46) | GRIN2CKMT2AMEN1MAPTRAB9A | |
| SCHEMBL5551087 | 0.74 | MAPK1 (0.53) | ALDH1A1GRIN2CKMT2AMEN1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070010556-A1 | Thiophene derivatives as chk 1 inhibitors | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010556-A1 | Thiophene derivatives as chk 1 inhibitors | CHEK1, CHKA, CHEK2 | ALDH1A1 2326/4885GRIN2C 4559/4885KMT2A 2078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.