Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 4/20 | 0.40 |
| ▸ | ACACA | Q13085 | 4/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | SPR | P35270 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3400872 | 0.81 | LMNA (0.46) | HTR2CKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL13072005 | 0.81 | KDM4E (0.43) | KDM4EALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL14545934 | 0.80 | KDM4E (0.43) | KDM4EALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL3405422 | 0.79 | LMNA (0.48) | HTR2CKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14545939 | 0.78 | ACACB (0.44) | HTR2CKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL5549726 | 0.78 | GAA (0.35) | HTR2CKDM4EALDH1A1 | |
| SCHEMBL3401298 | 0.78 | HTR2C (0.46) | HTR2CKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL14546059 | 0.77 | HRH3 (0.46) | HTR2CKDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL3405430 | 0.76 | ACACB (0.47) | KDM4EALDH1A1MEN1KMT2AHIF1A | |
| SCHEMBL3401027 | 0.76 | HTR2C (0.46) | HTR2CKDM4EALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848428-A2 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORPORATION (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089076-A2 | THIAZOLE AMIDES, IMIDAZOLE AMIDES AND RELATED ANALOGUES | NEUROGEN CORPORATION (US) | 2006-08-24 | — | — | WO | disclosed |