Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 7/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 7/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.51 |
| ▸ | PPARG | P37231 | 9/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | AKR1C4 | P17516 | 2/20 | 0.48 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.48 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.48 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6423095 | 0.93 | PPARG (0.46) | AKR1C3AKR1C2PTGS1PTGS2PPARG | |
| SCHEMBL5798795 | 0.91 | AKR1C3 (0.58) | AKR1C3AKR1C2PTGS1PTGS2PPARG | |
| SCHEMBL5452301 | 0.90 | AKR1C3 (0.63) | AKR1C3AKR1C2PTGS1PTGS2PPARG | |
| SCHEMBL5799139 | 0.90 | PTGS2 (0.54) | AKR1C3AKR1C2PTGS1PTGS2PPARG | |
| SCHEMBL5800524 | 0.88 | AKR1C3 (0.50) | AKR1C3AKR1C2PTGS1PTGS2PPARG | |
| SCHEMBL6426589 | 0.87 | PPARG (0.48) | AKR1C3AKR1C2PTGS1PTGS2PPARG | |
| SCHEMBL6425169 | 0.87 | PPARG (0.48) | AKR1C3AKR1C2PTGS1PTGS2PPARG | |
| SCHEMBL6424034 | 0.87 | PPARG (0.48) | AKR1C3AKR1C2PTGS1PTGS2PPARG | |
| SCHEMBL6425166 | 0.87 | PPARG (0.48) | AKR1C3AKR1C2PTGS1PTGS2PPARG | |
| SCHEMBL6426587 | 0.87 | PPARG (0.48) | AKR1C3AKR1C2PTGS1PTGS2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1643961-A4 | COX-2 AND FAAH INHIBITORS | MICROBIA INC (US) | 2007-09-12 | — | — | EP | disclosed |
| EP-1643961-A2 | COX-2 AND FAAH INHIBITORS | Microbia, Inc. (US) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005002525-A2 | COX-2 AND FAAH INHIBITORS | MICROBIA, INC. (US) | 2005-01-13 | — | — | WO | disclosed |