Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 0.68 |
| ▸ | ERBB2 | P04626 | 17/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.68 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.68 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.68 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.68 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | ABL1 | P00519 | 1/20 | 0.68 |
| ▸ | INSR | P06213 | 1/20 | 0.68 |
| ▸ | RET | P07949 | 1/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.68 |
| ▸ | SRC | P12931 | 1/20 | 0.68 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.68 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.68 |
| ▸ | CDK2 | P24941 | 1/20 | 0.68 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20041998 | 0.82 | EGFR (0.72) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| SCHEMBL14090716 | 0.81 | EGFR (0.79) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| Lapatinib SCHEMBL16766960 | 0.81 | EGFR (1.00) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| Lapatinib SCHEMBL8100 | 0.81 | EGFR (1.00) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| Lapatinib SCHEMBL29351024 | 0.81 | EGFR (1.00) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| Lapatinib SCHEMBL29464189 | 0.81 | EGFR (1.00) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| Lapatinib SCHEMBL3637153 | 0.80 | EGFR (0.99) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| Lapatinib SCHEMBL4924110 | 0.80 | EGFR (0.99) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| Lapatinib SCHEMBL3232064 | 0.80 | EGFR (0.99) | EGFRERBB2MEN1KMT2ACYP3A4 | |
| Lapatinib SCHEMBL574229 | 0.80 | EGFR (0.99) | EGFRERBB2MEN1KMT2ACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012156756-A2 | NEW COMPOUNDS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-11-22 | — | — | WO | disclosed |
| EP-2524918-A1 | Imidazopyrazines derivates as kinase inhibitors | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2012-11-21 | — | — | EP | disclosed |
| WO-2012052745-A1 | COMBINATIONS OF PI3K INHIBITORS WITH A SECOND ANTI -TUMOR AGENT | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2012-04-26 | — | — | WO | disclosed |
| WO-2011101644-A1 | TRIAZOLO [4, 5 - B] PYRIDIN DERIVATIVES | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2011-08-25 | — | — | WO | disclosed |
| WO-2011089400-A1 | INHIBITORS OF PI3 KINASE | CENTRO NACIONAL DE INVESTIGACIONES ONCOLÓGICAS (CNIO) (ES) | 2011-07-28 | — | — | WO | disclosed |
| WO-2008067144-A2 | CANCER TREATMENT METHOD | SMITHKLINE BEECHAM (CORK) LIMITED (IE) | 2008-06-05 | — | — | WO | disclosed |
| WO-2008063853-A2 | CANCER TREATMENT METHOD | SMITHKLINE BEECHAM (CORK) LIMITED (IE) | 2008-05-29 | — | — | WO | disclosed |