Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | MDM2 | Q00987 | 9/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | HSD17B2 | P37059 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 5/20 | 0.37 |
| ▸ | FNTA | P49354 | 2/20 | 0.36 |
| ▸ | FNTB | P49356 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5555478 | 0.88 | PDE4A (0.41) | PDE4APDE4BPDE4CPDE4DMDM2 | |
| SCHEMBL5562152 | 0.80 | FNTA (0.52) | PDE4APDE4BPDE4CPDE4DMDM2 | |
| SCHEMBL5561611 | 0.79 | HTT (0.46) | PDE4APDE4BPDE4CPDE4DMDM2 | |
| SCHEMBL5562507 | 0.76 | BRD4 (0.40) | PDE4APDE4BPDE4CPDE4DMDM2 | |
| SCHEMBL5562497 | 0.74 | MEN1 (0.42) | MDM2BRD4HSD17B2TP53MAPT | |
| SCHEMBL6348283 | 0.69 | MEN1 (0.55) | HTTTP53ALDH1A1TSHR | |
| SCHEMBL4376572 | 0.68 | MDM2 (0.39) | MDM2HTTTP53FNTAFNTB | |
| SCHEMBL6002784 | 0.66 | ACP3 (0.44) | MAPTTSHR | |
| SCHEMBL5561754 | 0.66 | HTT (0.44) | PDE4APDE4BPDE4CPDE4DMDM2 | |
| SCHEMBL10113390 | 0.65 | KMT2A (0.73) | HTTTP53ALDH1A1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977750-B1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA NV (BE) | 2007-07-04 | — | — | EP | disclosed |
| US-6358961-B1 | ADMINISTERING QUINAZOLINE DERIVATIVE FOR INHIBITING TUMOR GROWTH IN MAMMALS | JANNSEN-CILAG S.A. (FR) | 2002-03-19 | — | — | US | disclosed |
| US-6177432-B1 | ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS | JANSSEN-CILAG S.A. (FR) | 2001-01-23 | — | — | US | disclosed |
| EP-0977750-A1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049157-A1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-11-05 | — | — | WO | disclosed |