Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 10/20 | 0.52 |
| ▸ | FNTB | P49356 | 10/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.38 |
| ▸ | PGGT1B | P53609 | 5/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5555478 | 0.80 | PDE4A (0.41) | FNTAFNTBBRD4PDE4APDE4B | |
| SCHEMBL5556337 | 0.80 | PDE4A (0.41) | FNTAFNTBBRD4PDE4APDE4B | |
| SCHEMBL4371953 | 0.77 | FNTA (0.47) | FNTAFNTBPGGT1BMDM2 | |
| SCHEMBL4372100 | 0.75 | FNTA (0.46) | FNTAFNTBPGGT1BMDM2 | |
| SCHEMBL4372579 | 0.74 | FNTA (0.49) | FNTAFNTBPGGT1BMDM2IDO1 | |
| SCHEMBL4376761 | 0.73 | FNTA (0.43) | FNTAFNTBMDM2IDO1 | |
| SCHEMBL4377464 | 0.71 | FNTA (0.45) | FNTAFNTB | |
| SCHEMBL13501471 | 0.71 | FNTA (0.38) | FNTAFNTBPGGT1B | |
| SCHEMBL13899792 | 0.71 | FNTA (0.38) | FNTAFNTBPGGT1BMDM2 | |
| SCHEMBL5562507 | 0.69 | BRD4 (0.40) | FNTAFNTBBRD4PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0977750-B1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA NV (BE) | 2007-07-04 | — | — | EP | disclosed |
| US-6358961-B1 | ADMINISTERING QUINAZOLINE DERIVATIVE FOR INHIBITING TUMOR GROWTH IN MAMMALS | JANNSEN-CILAG S.A. (FR) | 2002-03-19 | — | — | US | disclosed |
| US-6177432-B1 | ANTICARCINOGENIC AGENTS, ANTITUMOR AGENTS | JANSSEN-CILAG S.A. (FR) | 2001-01-23 | — | — | US | disclosed |
| EP-0977750-A1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA N.V. (BE) | 2000-02-09 | — | — | EP | disclosed |
| WO-1998049157-A1 | FARNESYLTRANSFERASE INHIBITING QUINAZOLINONES | JANSSEN PHARMACEUTICA N.V. (BE) | 1998-11-05 | — | — | WO | disclosed |